Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid: Opposite behavior of TNF-alpha, Interleukin-4 and Interleukin-10

B. Giacalone; L. D'Auria; C. Bonifati; C. Ferraro; E. Riccardi; A. Mussi; G. D'Agosto; P. Cordiali-Fei; F. Ameglio

Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid: Opposite behavior of TNF-alpha, Interleukin-4 and Interleukin-10

B. Giacalone, L. D'Auria, C. Bonifati, C. Ferraro, E. Riccardi, A. Mussi, G. D'Agosto, P. Cordiali-Fei, F. Ameglio

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

This study analyzes both the blister fluid (BF) and serum levels of IL- 7 and TGF-beta₁ in samples from 18 patients affected with bullous pemphigoid (BP). These cytokines clearly present lower concentrations (P1 variations were observed between normal and pathologic serum samples. In addition, the serum levels detected in BP patients were significantly correlated with disease intensity (r=0.64, P=0.003, evaluated as the number of blisters/erosions for each patient) as well as with the peripheral B-lymphocyte counts (r=0.80, P1 and IL-4, whose levels are elevated in BP BFs) as opposed to an increased peripheral release of the same modulator. The IL-7 reduction may have a biological relevance in controlling a chronic, progressive disease.

Original language	English
Pages (from-to)	157-161
Number of pages	5
Journal	Experimental Dermatology
Volume	7
Issue number	4
Publication status	Published - Aug 1998

Keywords

Blister fluid
Bullous pemphigoid
IL-4
IL-7
Serum
TGF-β
TNF-α

ASJC Scopus subject areas

Dermatology

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Giacalone, B., D'Auria, L., Bonifati, C., Ferraro, C., Riccardi, E., Mussi, A., D'Agosto, G., Cordiali-Fei, P., & Ameglio, F. (1998). Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid: Opposite behavior of TNF-alpha, Interleukin-4 and Interleukin-10. Experimental Dermatology, 7(4), 157-161.

Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid : Opposite behavior of TNF-alpha, Interleukin-4 and Interleukin-10. / Giacalone, B.; D'Auria, L.; Bonifati, C. et al.

In: Experimental Dermatology, Vol. 7, No. 4, 08.1998, p. 157-161.

Research output: Contribution to journal › Article › peer-review

Giacalone, B, D'Auria, L, Bonifati, C, Ferraro, C, Riccardi, E, Mussi, A , D'Agosto, G, Cordiali-Fei, P & Ameglio, F 1998, 'Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid: Opposite behavior of TNF-alpha, Interleukin-4 and Interleukin-10', Experimental Dermatology, vol. 7, no. 4, pp. 157-161.

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abstract = "This study analyzes both the blister fluid (BF) and serum levels of IL- 7 and TGF-beta1 in samples from 18 patients affected with bullous pemphigoid (BP). These cytokines clearly present lower concentrations (P1 variations were observed between normal and pathologic serum samples. In addition, the serum levels detected in BP patients were significantly correlated with disease intensity (r=0.64, P=0.003, evaluated as the number of blisters/erosions for each patient) as well as with the peripheral B-lymphocyte counts (r=0.80, P1 and IL-4, whose levels are elevated in BP BFs) as opposed to an increased peripheral release of the same modulator. The IL-7 reduction may have a biological relevance in controlling a chronic, progressive disease.",

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Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid: Opposite behavior of TNF-alpha, Interleukin-4 and Interleukin-10

Abstract

Keywords

ASJC Scopus subject areas

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