Decreased NK activity in hairy cell leukemia (HCL): An analysis at the cellular level

L. Fontana, G. De Rossi, G. De Sanctis, F. Ensoli, M. Lopez, L. Annino, F. Mandelli

Research output: Contribution to journalArticle

Abstract

Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalBlut
Volume53
Issue number2
DOIs
Publication statusPublished - Aug 1986

Keywords

  • Hairy Cell Leukemia
  • Membrane phenotype
  • NK activity
  • Single cell cytotoxicity assay

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Fontana, L., De Rossi, G., De Sanctis, G., Ensoli, F., Lopez, M., Annino, L., & Mandelli, F. (1986). Decreased NK activity in hairy cell leukemia (HCL): An analysis at the cellular level. Blut, 53(2), 107-113. https://doi.org/10.1007/BF00321093