Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis

Giuliana Fortunato, Maria Donata Di Taranto, Umberto Marcello Bracale, Luca Del Guercio, Francesca Carbone, Cristina Mazzaccara, Alberto Morgante, Francesco Paolo D'Armiento, Maria D'Armiento, Massimo Porcellini, Lucia Sacchetti, Giancarlo Bracale, Francesco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Many gene products involved in oxidation and inflammation are implicated in the pathogenesis of atherosclerosis. We investigated paraoxonase 2 (PON2), 5-lipoxygenase (5-LO), and 5-LO activating protein (FLAP) expression and malondialdehyde (MDA) levels in carotid lesions to assess their involvement in plaque formation. Methods and Results: We measured gene expression and MDA levels in atherosclerotic plaques from 59 patients undergoing carotid endarterectomy, and in plaque-adjacent tissue from 41/59 patients. Twenty-three fetal carotids and 6 mammary arteries were also investigated. Real-time polymerase chain reaction and immunohistochemistry revealed decreased PON2 expression in plaques versus adjacent regions (P

Original languageEnglish
Pages (from-to)594-600
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1 2008

Keywords

  • Atherosclerosis
  • Carotid plaque
  • Fetal carotid and mammary artery
  • Oxidative stress
  • Paraoxonase 2 (PON2)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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