Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease

F. di Michele, P. Longone, E. Romeo, S. Lucchetti, L. Brusa, M. Pierantozzi, A. Bassi, G. Bernardi, P. Stanzione

Research output: Contribution to journalArticle

Abstract

The levels of the neuroactive steroids allopregnanolone (THP) and 5α-dihydroprogesterone (DHP) were quantified in the plasma of 11 (group 1) and in the liquor of 12 (group 2) Parkinson's disease (PD) patients using a gas-chromatographic/mass-spectrometric method. When compared with controls, both groups showed a significant decrease in DHP and THP concentrations. These decreases could be a useful marker of PD. Moreover, in view of the importance of GABA-ergic transmission to substantia nigra (SN) neurons and GABA-ergic modulation exerted by the two neuroactive steroids, our data indicate a global dysregulation of the SN GABA-ergic system in PD patients. Moreover, a lack of neuroprotective factors (i.e., GDNF, BDNF), promoted by DHP, may contribute to dopaminergic cell death.

Original languageEnglish
Pages (from-to)172-173
Number of pages2
JournalNeurological Sciences
Volume24
Issue number3
DOIs
Publication statusPublished - Oct 2003

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

di Michele, F., Longone, P., Romeo, E., Lucchetti, S., Brusa, L., Pierantozzi, M., Bassi, A., Bernardi, G., & Stanzione, P. (2003). Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease. Neurological Sciences, 24(3), 172-173. https://doi.org/10.1007/s10072-003-0115-1