Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti; Enrica Tamburrini; Enzo Ragazzoni; Andrea De Luca; Pierluigi Navarra

doi:10.3851/IMP1473

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Carmela Pinnetti, Enrica Tamburrini, Enzo Ragazzoni, Andrea De Luca, Pierluigi Navarra

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

Original language	English
Pages (from-to)	127-129
Number of pages	3
Journal	Antiviral Therapy
Volume	15
Issue number	1
DOIs	https://doi.org/10.3851/IMP1473
Publication status	Published - 2010

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)
Pharmacology

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10.3851/IMP1473

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abstract = "We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.",

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AU - De Luca, Andrea

AU - Navarra, Pierluigi

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Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Abstract

ASJC Scopus subject areas

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