Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment

R. Ghidoni; L. Benussi; M. Glionna; M. Franzoni; D. Geroldi; E. Emanuele; G. Binetti

doi:10.1007/s00702-008-0069-9

Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment

R. Ghidoni, L. Benussi, M. Glionna, M. Franzoni, D. Geroldi, E. Emanuele, G. Binetti

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Growing evidence advanced the idea that the soluble form of the receptor for advanced glycation end-products (sRAGE) might serve as a risk marker for several disorders including Alzheimer disease. We found a reduced level of circulating sRAGE in patients with mild cognitive impairment (MCI). The reduction of sRAGE in MCI, as well as the anticipation of the disease in patients with the lowest sRAGE levels (≤225 pg/ml), suggest a role of the RAGE axis in the pathogenesis of the disease.

Original language	English
Pages (from-to)	1047-1050
Number of pages	4
Journal	Journal of Neural Transmission
Volume	115
Issue number	7
DOIs	https://doi.org/10.1007/s00702-008-0069-9
Publication status	Published - Jul 2008

Keywords

AD
Biological marker
Cognitive decline
Mild cognitive impairment
Plasma
sRAGE

ASJC Scopus subject areas

Neuroscience(all)

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10.1007/s00702-008-0069-9

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abstract = "Growing evidence advanced the idea that the soluble form of the receptor for advanced glycation end-products (sRAGE) might serve as a risk marker for several disorders including Alzheimer disease. We found a reduced level of circulating sRAGE in patients with mild cognitive impairment (MCI). The reduction of sRAGE in MCI, as well as the anticipation of the disease in patients with the lowest sRAGE levels (≤225 pg/ml), suggest a role of the RAGE axis in the pathogenesis of the disease.",

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AU - Benussi, L.

AU - Glionna, M.

AU - Franzoni, M.

AU - Geroldi, D.

AU - Emanuele, E.

AU - Binetti, G.

PY - 2008/7

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AB - Growing evidence advanced the idea that the soluble form of the receptor for advanced glycation end-products (sRAGE) might serve as a risk marker for several disorders including Alzheimer disease. We found a reduced level of circulating sRAGE in patients with mild cognitive impairment (MCI). The reduction of sRAGE in MCI, as well as the anticipation of the disease in patients with the lowest sRAGE levels (≤225 pg/ml), suggest a role of the RAGE axis in the pathogenesis of the disease.

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KW - Cognitive decline

KW - Mild cognitive impairment

KW - Plasma

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Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment

Abstract

Keywords

ASJC Scopus subject areas

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