The course of two vascular activities (plasminogen activator and prostacyclin) was measured on venous specimens taken from rats before and during development of experimental venous thrombosis (induced by venous stasis). Vascular plasminogen activator activity (measured by a histochemical technique) increased immediately after ligature of the inferior vena cava, then progressively declined up till the appearance of a visible red thrombus; it virtually disappeared in concomitance with the formation and growth of the thrombus. Blood fibrinolytic activity closely followed the course of vascular plasminogen activator activity. In contrast, vascular prostacyclin (platelet aggregation inhibitory) activity remained within the normal range throughout the observation period (20 minutes - 48 hours). These results indicate that the course of two potential antithrombotic defence activities may be dissociated during the development of experimental venous thrombosis. The model used may provide some hints as to the relative roles of fibrinolytic and platelet inhibitory activities released from vascular endothelium in response to thrombogenic stimuli.
- experimental thrombosis
- Plasminogen activator
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine