Decreased plasminogen activator but normal prostacyclin activity in rat veins during development of experimental thrombosis

Michal Mysliwiec, Silvia Villa, Laura Kornblihtt, Giovanni de Gaetano, Maria Benedetta Donati

Research output: Contribution to journalArticle

Abstract

The course of two vascular activities (plasminogen activator and prostacyclin) was measured on venous specimens taken from rats before and during development of experimental venous thrombosis (induced by venous stasis). Vascular plasminogen activator activity (measured by a histochemical technique) increased immediately after ligature of the inferior vena cava, then progressively declined up till the appearance of a visible red thrombus; it virtually disappeared in concomitance with the formation and growth of the thrombus. Blood fibrinolytic activity closely followed the course of vascular plasminogen activator activity. In contrast, vascular prostacyclin (platelet aggregation inhibitory) activity remained within the normal range throughout the observation period (20 minutes - 48 hours). These results indicate that the course of two potential antithrombotic defence activities may be dissociated during the development of experimental venous thrombosis. The model used may provide some hints as to the relative roles of fibrinolytic and platelet inhibitory activities released from vascular endothelium in response to thrombogenic stimuli.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalThrombosis Research
Volume18
Issue number1-2
DOIs
Publication statusPublished - 1980

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Keywords

  • experimental thrombosis
  • Plasminogen activator
  • prostacyclin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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