Decreased platelet 3H-paroxetine binding in obsessive-compulsive patients

Donaiella Marazziti, Alessanara Rossi, Alfreáo Gemignani, Gino Giannaccini, Chiara Pfanner, Alessanaro Milanfranchi, Silvio Presta, Antonio Lucacchini, Giovanni B. Cassano

Research output: Contribution to journalArticle

Abstract

The similarities between the serotonin (5-HT) transporter in both human platelets and human brain permit us to investigate this structure in patients with different psychiatric disorders. Several reports have shown abnormalities of the 5-HT transporter, by means of the measurement of the 5-HT uptake or of the 3H-imipramine binding, in platelets of patients with obsessive-compulsive disorder (OCD). The availability of the ligand 3H-paroxetine, a selective 5-HT reuptake inhibitor, to label the 5-HT transporter, promoted us to evaluate the binding of 3H-paroxetine in platelets of 18 drug-free patients with OCD. The results, showing that the patients had a lower number of 3H-paroxetine sites, wich is inversely correlated with the Yale Brown Obsessive-Compulsive Scale total score, than a similar group of controls, add supporting evidence to the involvement of 5-HT in OCD. In addition, the decreased functionality of the 5-HT transporter seems to be linked to the severity of OC symptoms.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalNeuropsychobiology
Volume34
Issue number4
Publication statusPublished - 1996

Keywords

  • H-paroxetine
  • Blood platelets
  • Obsessive-compulsive disorder
  • Serotonin
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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    Marazziti, D., Rossi, A., Gemignani, A., Giannaccini, G., Pfanner, C., Milanfranchi, A., Presta, S., Lucacchini, A., & Cassano, G. B. (1996). Decreased platelet 3H-paroxetine binding in obsessive-compulsive patients. Neuropsychobiology, 34(4), 184-187.