Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis

Carlo Ferrarese, G. Sala, R. Riva, B. Begni, C. Zoia, L. Tremolizzo, G. Galimberti, A. Millul, A. Bastone, T. Mennini, C. Balzarini, L. Frattola, E. Beghi, A. Micheli, G. Moretto, C. Caponnetto, M. Ceroni, D. Alimonti, G. Siciliano, E. PastoriniM. Bonomi, L. Carvelli

Research output: Contribution to journalArticlepeer-review

Abstract

Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p <0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalNeurology
Volume56
Issue number2
Publication statusPublished - Jan 23 2001

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis'. Together they form a unique fingerprint.

Cite this