Decreased serum levels of insulin-like growth factor (IGF)-I in patients with lung cancer: Temporal relationship with growth hormone (GH) levels

Gianluigi Mazzoccoli, Antonio Giuliani, Giovanni Bianco, Angelo De Cata, Mario Balzanelli, Angelo Michele Carella, Marco La Viola, Roberto Tarquini

Research output: Contribution to journalArticle

Abstract

Aims and background: Several studies have evidenced that IGF-1 may play a role in the growth regulation of many cancer cell lines, and recently GH and IGF-1 have been recognized as stimulators of lymphopoiesis and immune function. We investigated whether there are any differences among health old people and old people suffering from lung cancer at different stages of disease in the 24-hour secretory profiles of GH and IGF-1. Methods: The study was carried out on seven healthy volunteers (mean age ± s.e. 68.8 + 1.92), seven patients with I and II stage lung cancer (mean age ± s.e. 67.2 ± 0.80) and seven patients with III and IV stage lung cancer (mean age ± s.e 69.5 ± 2.26). GH and IGF-1 serum levels were measured on blood samples collected every four hours for 24 hours; the area under the curve (AUC) and the presence of circadian rhythmicity were evaluated. Results: A normal circadian rhythmicity was recognizable only for GH secretion in healthy subjects. A progressive increase of GH serum levels and a steady decrease of IGF-1 serum levels were observed in cancer patients in relation to advancing stage of neoplastic disease. Conclusions: Lung cancer is associated with an altered regulation of GH-IGF-1 system, that might play a role in the clinical course of neoplastic disease.

Original languageEnglish
Pages (from-to)1397-1399
Number of pages3
JournalAnticancer Research
Volume19
Issue number2 B
Publication statusPublished - 1999

Keywords

  • Circadian rhythm
  • Growth hormone
  • Insulin-like growth factor I
  • Lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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