Decreased sympathetic inhibition in gastroesophageal reflux disease

S. M A Campo, A. Capria, F. Antonucci, G. Martino, A. Ciamei, P. M. Rossini, E. Bologna, D. Cannata

Research output: Contribution to journalArticlepeer-review


This study was undertaken to evaluate autonomic nervous system function in patients with gastroesophageal reflux disease. Based on clinical criteria, 28 consecutive patients with no history of heart, metabolic, or neurologic disease (mean age 41 y, range 20-62 y) reporting with upper gastrointestinal symptoms typical of gastroesophageal reflux underwent esophageal manometry, ambulatory 24-hour pH study with electrocardiographic monitoring, power spectral analysis of heart rate variability, and cardiovascular tests. Twelve healthy subjects served as controls. A positive result of prolonged esophageal pH study (pH in the distal esophagus less than 4, lasting more than 4.2% of recording time) was observed in 21 patients (reflux group); seven patients were categorized in the nonreflux group. No patient showed arrhythmias or any correlation between heart rate variability changes during electrocardiographic monitoring and episodes of reflux (pH less than 4, lasting more than 5 minutes). A decrease of sympathetic function occurred only in the reflux group (p

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalClinical Autonomic Research
Issue number1
Publication statusPublished - 2001


  • Autonomic nervous system
  • Gastroesophageal reflux

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Decreased sympathetic inhibition in gastroesophageal reflux disease'. Together they form a unique fingerprint.

Cite this