DNA damage induced in vivo by 3′-methyl-4-dimethylaminoazobenzene (3′CH3DAB) was investigated with 2 differently sensitive techniques: the alkaline elution assay and the visometric measurement of DNA damage. 3′CH3DAB appeared to be falsely negative with the alkaline elution assay, whereas with the viscometric approach, which is about 30-50 times more sensitive, it appeared positive, and the DNA damage was dose-dependent.
|Number of pages||9|
|Journal||Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis