Decreased viscosity of rat-liver DNA treated by 3′-methyl-4-dimethylaminoazobenzene, detected with a new viscometric approach

S. Parodi, C. Balbi, M. Taningher, M. Pala, P. Russo, M. L. Abelmoschi, L. Santi

Research output: Contribution to journalArticle

Abstract

DNA damage induced in vivo by 3′-methyl-4-dimethylaminoazobenzene (3′CH3DAB) was investigated with 2 differently sensitive techniques: the alkaline elution assay and the visometric measurement of DNA damage. 3′CH3DAB appeared to be falsely negative with the alkaline elution assay, whereas with the viscometric approach, which is about 30-50 times more sensitive, it appeared positive, and the DNA damage was dose-dependent.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume106
Issue number1
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Fingerprint Dive into the research topics of 'Decreased viscosity of rat-liver DNA treated by 3′-methyl-4-dimethylaminoazobenzene, detected with a new viscometric approach'. Together they form a unique fingerprint.

  • Cite this