Decreasing arterial aging by controlling blood pressure levels and hypertension: A step forward

Angelo Scuteri, Pedro Guimarães Cunha

Research output: Contribution to journalArticlepeer-review

Abstract

Arterial aging, characterized by arterial stiffening that is clinically evaluable as aortic pulse wave velocity, is risky for CV events, disability, and loss of cognitive function. Today the only adopted strategy to decrease arterial aging/ arterial stiffness is represented by decreasing BP. Selective antihypertensive drug classes (calcium channel blockers, converting enzyme inhibitors, angiotensin type 1 receptor antagonists) showed a beneficial effect on the arterial wall and on both large and small arteries over and above the reduction in BP levels. Still, the lower the better paradigm seems only to expose older subjects to higher rate of side effects, that via hypotension result in even transient organ hypoperfusion. This vicious circle may be particularly detrimental for cerebral district and, thus, for cognitive impairment onset and progression until dementia.

Original languageEnglish
Pages (from-to)702-704
Number of pages3
JournalCurrent Vascular Pharmacology
Volume10
Issue number6
DOIs
Publication statusPublished - 2012

Keywords

  • Arterial aging
  • Cognitive impairment
  • Hypertension treatment
  • Hypotension
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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