Dedifferentiated chondrosarcoma with "adamantinoma-like" features: A case report and review of literature

Marco Gambarotti, Alberto Righi, Tommaso Frisoni, Davide Maria Donati, Daniel Vanel, Marta Sbaraglia, Angelo P. Dei Tos

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Dedifferentiated chondrosarcoma is defined by the presence of a low grade malignant cartilaginous component juxtaposed to a high grade malignant non-cartilaginous sarcomatous components. Only 4 cases in which the high grade component showed epithelial differentiation have been reported in the literature; three featured a squamous and the one a glandular epithelial component. Here we describe a case of dedifferentiated chondrosarcoma exhibiting epithelial "adamantinoma-like" basaloid features. The patient underwent wide resection of the proximal tibia and post-operative chemotherapy and died 8 months after the diagnosis due to lung and bone metastases.
Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalPathology Research and Practice
Issue number6
Publication statusPublished - May 6 2017


  • Adamantinoma-like
  • Basaloid
  • Dedifferentiated chondrosarcoma
  • Epithelial


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