Deep brain electrophysiological recordings provide clues to the pathophysiology of Tourette syndrome

Alberto Priori, Gaia Giannicola, Manuela Rosa, Sara Marceglia, Domenico Servello, Marco Sassi, Mauro Porta

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Although ample evidence suggests that high-frequency deep brain stimulation (DBS) is an effective therapy in patients with Tourette syndrome (TS), its pathophysiology and the neurophysiological mechanisms underlying these benefits remain unclear. The DBS targets mainly used to date in TS are located within the basal ganglia-thalamo-cortical circuit compromised in this syndrome: the medial and ventral thalamic nuclei, which are way stations within the circuit, the globus pallidus and the nucleus accumbens. Neuronal activity can be electrophysiologically recorded from deep brain structures during DBS surgery (intraoperative microrecordings) or within few days after DBS electrode implantation (local field potentials, LFPs). Recordings from the thalamus in patients with TS showed that the power in low-frequency oscillations (2-15. Hz) was higher than power in high frequency oscillations (

Original languageEnglish
Pages (from-to)1063-1068
Number of pages6
JournalNeuroscience and Biobehavioral Reviews
Volume37
Issue number6
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Tourette Syndrome
Deep Brain Stimulation
Brain
Ventral Thalamic Nuclei
Mediodorsal Thalamic Nucleus
Globus Pallidus
Nucleus Accumbens
Basal Ganglia
Thalamus
Electrodes
Power (Psychology)
Therapeutics

Keywords

  • Adaptive deep brain stimulation
  • Deep brain stimulation
  • Local field potentials
  • Long term recordings
  • Low-frequency
  • Microrecordings
  • Movement disorders
  • Neurophysiology
  • Neurosurgery
  • Pathophysiology
  • Tic
  • Tourette syndrome

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology
  • Medicine(all)

Cite this

Deep brain electrophysiological recordings provide clues to the pathophysiology of Tourette syndrome. / Priori, Alberto; Giannicola, Gaia; Rosa, Manuela; Marceglia, Sara; Servello, Domenico; Sassi, Marco; Porta, Mauro.

In: Neuroscience and Biobehavioral Reviews, Vol. 37, No. 6, 07.2013, p. 1063-1068.

Research output: Contribution to journalArticle

Priori, Alberto ; Giannicola, Gaia ; Rosa, Manuela ; Marceglia, Sara ; Servello, Domenico ; Sassi, Marco ; Porta, Mauro. / Deep brain electrophysiological recordings provide clues to the pathophysiology of Tourette syndrome. In: Neuroscience and Biobehavioral Reviews. 2013 ; Vol. 37, No. 6. pp. 1063-1068.
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