Deep brain stimulation (DBS) attentional effects parallel those of l-dopa treatment

L. Brusa, M. Pierantozzi, A. Peppe, M. G. Altibrandi, P. Giacomini, P. Mazzone, P. Stanzione

Research output: Contribution to journalArticlepeer-review

Abstract

Aim of our study was to investigate the different effects on attentional capacity of deep brain stimulation DBS (STN or GPi) and of l-dopa in PD patients. Patients were evaluated on-DBS/off-l-dopa, on-l-dopa/off-DBS, on-l-dopa/on-DBS and off-l-dopa/off-DBS. Our results indicate that DBS effects on attentional functions parallel those of l-dopa. A site independent (both STN and GPi) worsening of verbal fluency was observed, possibly connected to the stimulus effect on the cortico-subcortical-cortical loop.

Original languageEnglish
Pages (from-to)1021-1027
Number of pages7
JournalJournal of Neurology
Volume248
Issue number9
Publication statusPublished - 2001

Keywords

  • Attentional capacity
  • DBS
  • l-dopa

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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