Abstract
Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.
| Original language | English |
|---|---|
| Journal | World Neurosurgery |
| Volume | 80 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Sep 2013 |
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Keywords
- Aggressive behavior
- Deep brain stimulation
- Posterior hypothalamus
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Deep-brain stimulation for aggressive and disruptive behavior. / Franzini, Angelo; Broggi, Giovanni; Cordella, Roberto; Dones, Ivano; Messina, Giuseppe.
In: World Neurosurgery, Vol. 80, No. 3-4, 09.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deep-brain stimulation for aggressive and disruptive behavior
AU - Franzini, Angelo
AU - Broggi, Giovanni
AU - Cordella, Roberto
AU - Dones, Ivano
AU - Messina, Giuseppe
PY - 2013/9
Y1 - 2013/9
N2 - Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.
AB - Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.
KW - Aggressive behavior
KW - Deep brain stimulation
KW - Posterior hypothalamus
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U2 - 10.1016/j.wneu.2012.06.038
DO - 10.1016/j.wneu.2012.06.038
M3 - Article
C2 - 22743202
AN - SCOPUS:84885162615
VL - 80
JO - World Neurosurgery
JF - World Neurosurgery
SN - 1878-8750
IS - 3-4
ER -