Abstract
Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.
Original language | English |
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Journal | World Neurosurgery |
Volume | 80 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - Sep 2013 |
Keywords
- Aggressive behavior
- Deep brain stimulation
- Posterior hypothalamus
ASJC Scopus subject areas
- Clinical Neurology
- Surgery