Deep-brain stimulation for aggressive and disruptive behavior

Angelo Franzini, Giovanni Broggi, Roberto Cordella, Ivano Dones, Giuseppe Messina

Research output: Contribution to journalArticle

Abstract

Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.

Original languageEnglish
JournalWorld Neurosurgery
Volume80
Issue number3-4
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Deep Brain Stimulation
Posterior Hypothalamus
Aggression
Intellectual Disability
General Anesthesia
Safety
Therapeutics
Pharmaceutical Preparations
Problem Behavior

Keywords

  • Aggressive behavior
  • Deep brain stimulation
  • Posterior hypothalamus

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Deep-brain stimulation for aggressive and disruptive behavior. / Franzini, Angelo; Broggi, Giovanni; Cordella, Roberto; Dones, Ivano; Messina, Giuseppe.

In: World Neurosurgery, Vol. 80, No. 3-4, 09.2013.

Research output: Contribution to journalArticle

@article{6fa6c35eab7c4d868e19e9953752841f,
title = "Deep-brain stimulation for aggressive and disruptive behavior",
abstract = "Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.",
keywords = "Aggressive behavior, Deep brain stimulation, Posterior hypothalamus",
author = "Angelo Franzini and Giovanni Broggi and Roberto Cordella and Ivano Dones and Giuseppe Messina",
year = "2013",
month = "9",
doi = "10.1016/j.wneu.2012.06.038",
language = "English",
volume = "80",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",
number = "3-4",

}

TY - JOUR

T1 - Deep-brain stimulation for aggressive and disruptive behavior

AU - Franzini, Angelo

AU - Broggi, Giovanni

AU - Cordella, Roberto

AU - Dones, Ivano

AU - Messina, Giuseppe

PY - 2013/9

Y1 - 2013/9

N2 - Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.

AB - Objective: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. Methods: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. Results: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. Conclusions: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.

KW - Aggressive behavior

KW - Deep brain stimulation

KW - Posterior hypothalamus

UR - http://www.scopus.com/inward/record.url?scp=84885162615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885162615&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2012.06.038

DO - 10.1016/j.wneu.2012.06.038

M3 - Article

C2 - 22743202

AN - SCOPUS:84885162615

VL - 80

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

IS - 3-4

ER -