Deep brain stimulation for intractable chronic cluster headache: Proposals for patient selection

Massimo Leone, A. May, A. Franzini, G. Broggi, D. Dodick, A. Rapoport, P. J. Goadsby, J. Schoenen, V. Bonavita, G. Bussone

Research output: Contribution to journalArticle

Abstract

Cluster headache is the most severe of the primary headaches. Positron emission tomography and functional MRI studies have shown that the ipsilateral posterior hypothalamus is activated during cluster headache attacks and is structurally asymmetric in these patients. These changes are highly specific for the condition and suggest that the cluster headache generator may be located in that brain area; they further suggest that electrical stimulation of that region might produce clinical improvement in chronic cluster headache sufferers refractory to medical therapy. In five patients with severe intractable chronic cluster headache, hypothalamic electrical stimulation produced complete and long-term pain relief with no relevant side-effects. We therefore consider it essential to propose criteria for selecting chronic cluster headache patients for hypothalamic deep brain stimulation before this procedure is undertaken at other academic medical centres.

Original languageEnglish
Pages (from-to)934-937
Number of pages4
JournalCephalalgia
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 2004

Keywords

  • Cluster headache
  • Deep brain stimulation
  • Hypothalamus
  • Surgery
  • Therapy

ASJC Scopus subject areas

  • Clinical Neurology

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    Leone, M., May, A., Franzini, A., Broggi, G., Dodick, D., Rapoport, A., Goadsby, P. J., Schoenen, J., Bonavita, V., & Bussone, G. (2004). Deep brain stimulation for intractable chronic cluster headache: Proposals for patient selection. Cephalalgia, 24(11), 934-937. https://doi.org/10.1111/j.1468-2982.2004.00742.x