Deep brain stimulation for Parkinson′s disease prior to L-dopa treatment: A case report

Domenico Servello, Christian Saleh, Alberto R. Bona, Edvin Zekaj, Carlotta Zanaboni, Mauro Porta

Research output: Contribution to journalArticle

Abstract

Background: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson′s disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. Case Description: We present a male patient with a 9-year course of PD who at 53 years of age preferred deep brain stimulation (DBS) of the subthalamic nucleus over initial l-dopa treatment. The patient argued that he wanted to avoid the serious adverse effects of l-dopa, which would have presented within his time of full professional activity. DBS resulted in significant motor improvement lasting for 6 years without l-dopa treatment. Conclusion: Large multicentre-based international trials with long follow-ups are needed to answer the effectiveness of early DBS in PD.

Original languageEnglish
Pages (from-to)S827-S829
JournalSurgical Neurology International
Volume7
Issue number36
DOIs
Publication statusPublished - 2016

Keywords

  • Deep brain stimulation
  • L-dopa
  • Parkinson′s disease

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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