Deep brain stimulation for Parkinson's disease: The experience of the Policlinico-San Paolo group in Milan

F. Tamma, P. Rampini, M. Egidi, E. Caputo, M. Locatelli, A. Pesenti, V. Chiesa, G. Ardolino, G. Foffani, B. Meda, M. Pellegrini, A. Priori

Research output: Contribution to journalArticlepeer-review

Abstract

Thirty patients with idiopathic Parkinson's disease were treated with deep brain stimulation electrode in the subthalamic nucleus. After surgery, the patients' best mean Unified Parkinson's Disease Rating Scale (UPDRS III) scores (medictionOFF-stimulatorON versus preoperative medicationOFF) were 77±14% at 3 months (n=20 patients) and 72±14% at 12 months follow-up (n=16). The mean reduction in therapy (expressed in levodopa dose equivalents in mg) was 68±25% at 12 months. Postoperative complications were rare, mostly mild, and reversible. Therapeutic success depends on a multidisciplinary team approach, meticulous patient selection, including patients' cognitive, psychic, and behavioral status, and patient and family lifestyles.

Original languageEnglish
JournalNeurological Sciences
Volume24
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2003

Keywords

  • Basal ganglia
  • Deep brain stimulation
  • Movement disorders
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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