Deep brain stimulation for the treatment of Parkinson's disease: The experience of the neurosurgical department of Monza

A. Landi, M. Parolin, R. Piolti, A. Antonini, M. Grimaldi, M. Crespi, S. Iurlaro, A. Aliprandi, G. Pezzoli, C. Ferrarese, S. M. Gaini

Research output: Contribution to journalArticle

Abstract

Deep brain stimulation is a widely accepted surgical therapy for the symptomatic treatment of advanced parkinson's disease; high frequency chronic stimulation of the subthalamic nucleus proved its efficacy to control the major motor symptoms. In the neurosurgical department of Monza we treated 72 parkinsonian patients (November 1998-January 2003). One year follow-up results are: decrease of tremor 90%, hypertonous 56%, bradykinesia 70%, voice impairment amelioration 30%, mean total daily L-dopa intake reduced 58%. Freezing and balance did not ameliorate, some voice impairment and psychic derangement have been observed. Major surgical complications were: haemorrage (1 case - transient hemiparesis), infections (2 cases), pulmonary embolisation (1 case). To optimise the surgical results, careful clinical and instrumental selection of the patients are mandatory before surgery.

Original languageEnglish
JournalNeurological Sciences
Volume24
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2003

Keywords

  • Complications
  • Deep brain stimulation
  • Parkinson's disease
  • Results

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Landi, A., Parolin, M., Piolti, R., Antonini, A., Grimaldi, M., Crespi, M., Iurlaro, S., Aliprandi, A., Pezzoli, G., Ferrarese, C., & Gaini, S. M. (2003). Deep brain stimulation for the treatment of Parkinson's disease: The experience of the neurosurgical department of Monza. Neurological Sciences, 24(SUPPL. 1). https://doi.org/10.1007/s100720300039