Deep brain stimulation for treatment of refractory Tourette syndrome: Long-term follow-up

M. Porta, D. Servello, C. Zanaboni, F. Anasetti, C. Menghetti, M. Sassi, M. M. Robertson

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background Eighteen patients with severe and refractory Tourette Syndrome underwent bilateral thalamic deep brain stimulation. The surgical procedures and stimulation processes of the cohort were reported in 2008; the 2 year follow-up was reported in 2009. The aim of the research is the assessment of long-term outcome (5-6 years) on tics, obsessional behaviours, anxiety, mood, and on the overall general health of the patients and their general satisfaction. Method In this study, all 18 of the original patients will be discussed, pre- and post-DBS, according to our protocol using standardized objective schedules, as well as the clinical impressions of both clinicians and patients. As there were no substantial nor statistical differences on measures of cognitive functioning between pre-DBS and 2 year followup, we decided not to continue this aspect of the formal assessment, particularly as there were also no clinical indications. Results At 5-6 year follow-up, there was a significant reduction in tic severity (p

Original languageEnglish
Pages (from-to)2029-2041
Number of pages13
JournalActa Neurochirurgica
Volume154
Issue number11
DOIs
Publication statusPublished - Nov 2012

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Tourette Syndrome
Deep Brain Stimulation
Tics
Therapeutics
Appointments and Schedules
Anxiety
Health
Research

Keywords

  • Deep brain stimulation
  • Follow-up
  • Psychopathologies
  • Tourette syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Deep brain stimulation for treatment of refractory Tourette syndrome : Long-term follow-up. / Porta, M.; Servello, D.; Zanaboni, C.; Anasetti, F.; Menghetti, C.; Sassi, M.; Robertson, M. M.

In: Acta Neurochirurgica, Vol. 154, No. 11, 11.2012, p. 2029-2041.

Research output: Contribution to journalArticle

Porta, M. ; Servello, D. ; Zanaboni, C. ; Anasetti, F. ; Menghetti, C. ; Sassi, M. ; Robertson, M. M. / Deep brain stimulation for treatment of refractory Tourette syndrome : Long-term follow-up. In: Acta Neurochirurgica. 2012 ; Vol. 154, No. 11. pp. 2029-2041.
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