Deep brain stimulation in craniofacial pain: Seven years' experience

G. Bussone, A. Franzini, A. Proietti Cecchini, E. Mea, M. Curone, V. Tullo, G. Broggi, G. Casucci, V. Bonavita, M. Leone

Research output: Contribution to journalArticle

Abstract

Cluster headache (CH) is a primary headache with excruciatingly painful attacks that are strictly unilateral. About 10% of cases experience no significant remission, and about 15% of these do not respond to medication, so surgery is considered. Neuroimaging studies show that the posterior inferior hypothalamus is activated during CH attacks and is plausibly the CH generator. We report on 16 chronic CH patients, with headaches refractory to all medication, who received long-term hypothalamic stimulation following electrode implant to the posterior inferior hypothalamus. After a mean follow-up of 23 months, a persistent pain-free to almost pain-free state was achieved in 13/16 patients (15/18 implants; 83.3%) a mean of 42 days (range 1-86 days) after monopolar stimulation initiation. Ten patients (11 implants) are completely pain-free. A common side effect was transient diplopia, which limited stimulation amplitude. In one patient, a small non-symptomatic haemorrhage into the 3rd ventricle occurred following implant, but regressed 24 h later. Persistent side effects are absent except in one patient with bilateral stimulation, in whom stimulation was stopped to resolve vertigo and worsened bradycardia, but was resumed later without further problems. Hypothalamic stimulation is an effective, safe and well tolerated treatment for chronic drug-refractory CH. It appears as a valid alternative to destructive surgical modalities, and has the additional advantage of being reversible.

Original languageEnglish
JournalNeurological Sciences
Volume28
Issue numberSUPPL. 2
DOIs
Publication statusPublished - May 2007

Fingerprint

Cluster Headache
Facial Pain
Deep Brain Stimulation
Posterior Hypothalamus
Headache
Third Ventricle
Diplopia
Vertigo
Bradycardia
Neuroimaging
Electrodes
Hemorrhage
Pharmaceutical Preparations
Pain-Free

Keywords

  • Cluster headache
  • Deep brain stimulation
  • SUNCT
  • Surgery
  • Therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Deep brain stimulation in craniofacial pain : Seven years' experience. / Bussone, G.; Franzini, A.; Proietti Cecchini, A.; Mea, E.; Curone, M.; Tullo, V.; Broggi, G.; Casucci, G.; Bonavita, V.; Leone, M.

In: Neurological Sciences, Vol. 28, No. SUPPL. 2, 05.2007.

Research output: Contribution to journalArticle

Bussone, G, Franzini, A, Proietti Cecchini, A, Mea, E, Curone, M, Tullo, V, Broggi, G, Casucci, G, Bonavita, V & Leone, M 2007, 'Deep brain stimulation in craniofacial pain: Seven years' experience', Neurological Sciences, vol. 28, no. SUPPL. 2. https://doi.org/10.1007/s10072-007-0768-2
Bussone, G. ; Franzini, A. ; Proietti Cecchini, A. ; Mea, E. ; Curone, M. ; Tullo, V. ; Broggi, G. ; Casucci, G. ; Bonavita, V. ; Leone, M. / Deep brain stimulation in craniofacial pain : Seven years' experience. In: Neurological Sciences. 2007 ; Vol. 28, No. SUPPL. 2.
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