Deep brain stimulation in Parkinson's disease patients: Biochemical evidence

A. Stefani, E. Fedele, S. Galati, M. Raiteri, O. Pepicelli, L. Brusa, M. Pierantozzi, A. Peppe, A. Pisani, G. Gattoni, A. H. Hainsworth, G. Bernardi, P. Stanzione, P. Mazzone

Research output: Contribution to journalArticle

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Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) patients augments STN-driven excitation of the internal globus pallidus (GPi). However, other DBS-induced changes are largely unknown. Here we report the biochemical effects of STN-DBS in two basal ganglia stations (putamen - PUT - and GPi) and in a thalamic relay nucleus, the anteroventral thalamus (VA). In six advanced PD patients undergoing surgery, microdialysis samples were collected from GPi, PUT and VA before, during and after one hour of STN-DBS. cGMP was measured in the GPi and PUT as an index of glutamatergic transmission, whereas GABA was measured in the VA. During clinically effective STN-DBS, we found a significant decrease in GABA extracellular concentrations in the VA (-25%). Simultaneously, cGMP extracellular concentrations were enhanced in the PUT (+200%) and GPi (+481%). DBS differentially affects fibers crossing the STN area: it activates the STN-GPi pathway while inhibiting the GPi-VA one. These findings support a thalamic dis-inhibition, as the main responsible for the clinical effect of STN-DBS. This, in turn, re-establishes a more physiological level of PUT activity.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalJournal of Neural Transmission, Supplement
Issue number70
Publication statusPublished - 2006

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Subthalamic Nucleus
Deep Brain Stimulation
Globus Pallidus
Parkinson Disease
gamma-Aminobutyric Acid
Anterior Thalamic Nuclei
Putamen
Microdialysis
Basal Ganglia
Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

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Stefani, A., Fedele, E., Galati, S., Raiteri, M., Pepicelli, O., Brusa, L., ... Mazzone, P. (2006). Deep brain stimulation in Parkinson's disease patients: Biochemical evidence. Journal of Neural Transmission, Supplement, (70), 401-408.

Deep brain stimulation in Parkinson's disease patients : Biochemical evidence. / Stefani, A.; Fedele, E.; Galati, S.; Raiteri, M.; Pepicelli, O.; Brusa, L.; Pierantozzi, M.; Peppe, A.; Pisani, A.; Gattoni, G.; Hainsworth, A. H.; Bernardi, G.; Stanzione, P.; Mazzone, P.

In: Journal of Neural Transmission, Supplement, No. 70, 2006, p. 401-408.

Research output: Contribution to journalArticle

Stefani, A, Fedele, E, Galati, S, Raiteri, M, Pepicelli, O, Brusa, L, Pierantozzi, M, Peppe, A, Pisani, A, Gattoni, G, Hainsworth, AH, Bernardi, G, Stanzione, P & Mazzone, P 2006, 'Deep brain stimulation in Parkinson's disease patients: Biochemical evidence', Journal of Neural Transmission, Supplement, no. 70, pp. 401-408.
Stefani A, Fedele E, Galati S, Raiteri M, Pepicelli O, Brusa L et al. Deep brain stimulation in Parkinson's disease patients: Biochemical evidence. Journal of Neural Transmission, Supplement. 2006;(70):401-408.
Stefani, A. ; Fedele, E. ; Galati, S. ; Raiteri, M. ; Pepicelli, O. ; Brusa, L. ; Pierantozzi, M. ; Peppe, A. ; Pisani, A. ; Gattoni, G. ; Hainsworth, A. H. ; Bernardi, G. ; Stanzione, P. ; Mazzone, P. / Deep brain stimulation in Parkinson's disease patients : Biochemical evidence. In: Journal of Neural Transmission, Supplement. 2006 ; No. 70. pp. 401-408.
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