Deep medullary vein involvement in neonates with brain damage: An MR imaging study

Filippo Arrigoni, C. Parazzini, A. Righini, C. Doneda, L. A. Ramenghi, G. Lista, F. Triulzi

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Different and specific MR imaging patterns of lesions involving WM are widely defined in neonatal encephalopathy. The aim of this study was to describe a novel MR imaging pattern of damage characterized by the abnormal prominence of DMVs in premature and full-term neonates. MATERIALS AND METHODS: Twenty-one (11 premature and 10 full-term) neonates with MR imaging evidence of linear radially oriented fan-shaped lesions in the periventricular WM and without dural venous thrombosis were enrolled in this retrospective study. A total of 37 MR imaging examinations were performed at ages ranging from day 0 to 24 months. RESULTS: According to the appearance of linear anomalies on T2-weighted images, we identified 2 main patterns: T2 hypointense lesions without WM cavitations and T2 hypointense lesions associated with linear cysts. The first pattern was found in 17 examinations performed between 0 and 44 days of life; the second pattern was found in another 14 examinations performed between 6 days and 4 months of life. Five examinations performed between 9 and 24 months of life showed a reduction in volume and hyperintense signal intensity of the periventricularWMon T2-weighted and FLAIR images. CONCLUSIONS: Subtle linear WM lesions with the same anatomic distribution of DMVs may be evident in premature and full-term neonates without signs of major venous thrombosis, both in the acute and subacute phases. Their appearance and evolution suggest that transient DMV engorgement/ thrombosis may be responsible for WM damage that can lead to a PVL-like pattern.

Original languageEnglish
Pages (from-to)2030-2036
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume32
Issue number11
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Veins
Venous Thrombosis
Brain
Brain Diseases
Cysts
Thrombosis
Retrospective Studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Deep medullary vein involvement in neonates with brain damage : An MR imaging study. / Arrigoni, Filippo; Parazzini, C.; Righini, A.; Doneda, C.; Ramenghi, L. A.; Lista, G.; Triulzi, F.

In: American Journal of Neuroradiology, Vol. 32, No. 11, 12.2011, p. 2030-2036.

Research output: Contribution to journalArticle

@article{050b8c1f44a2416db1ad2028078b470f,
title = "Deep medullary vein involvement in neonates with brain damage: An MR imaging study",
abstract = "BACKGROUND AND PURPOSE: Different and specific MR imaging patterns of lesions involving WM are widely defined in neonatal encephalopathy. The aim of this study was to describe a novel MR imaging pattern of damage characterized by the abnormal prominence of DMVs in premature and full-term neonates. MATERIALS AND METHODS: Twenty-one (11 premature and 10 full-term) neonates with MR imaging evidence of linear radially oriented fan-shaped lesions in the periventricular WM and without dural venous thrombosis were enrolled in this retrospective study. A total of 37 MR imaging examinations were performed at ages ranging from day 0 to 24 months. RESULTS: According to the appearance of linear anomalies on T2-weighted images, we identified 2 main patterns: T2 hypointense lesions without WM cavitations and T2 hypointense lesions associated with linear cysts. The first pattern was found in 17 examinations performed between 0 and 44 days of life; the second pattern was found in another 14 examinations performed between 6 days and 4 months of life. Five examinations performed between 9 and 24 months of life showed a reduction in volume and hyperintense signal intensity of the periventricularWMon T2-weighted and FLAIR images. CONCLUSIONS: Subtle linear WM lesions with the same anatomic distribution of DMVs may be evident in premature and full-term neonates without signs of major venous thrombosis, both in the acute and subacute phases. Their appearance and evolution suggest that transient DMV engorgement/ thrombosis may be responsible for WM damage that can lead to a PVL-like pattern.",
author = "Filippo Arrigoni and C. Parazzini and A. Righini and C. Doneda and Ramenghi, {L. A.} and G. Lista and F. Triulzi",
year = "2011",
month = "12",
doi = "10.3174/ajnr.A2687",
language = "English",
volume = "32",
pages = "2030--2036",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "11",

}

TY - JOUR

T1 - Deep medullary vein involvement in neonates with brain damage

T2 - An MR imaging study

AU - Arrigoni, Filippo

AU - Parazzini, C.

AU - Righini, A.

AU - Doneda, C.

AU - Ramenghi, L. A.

AU - Lista, G.

AU - Triulzi, F.

PY - 2011/12

Y1 - 2011/12

N2 - BACKGROUND AND PURPOSE: Different and specific MR imaging patterns of lesions involving WM are widely defined in neonatal encephalopathy. The aim of this study was to describe a novel MR imaging pattern of damage characterized by the abnormal prominence of DMVs in premature and full-term neonates. MATERIALS AND METHODS: Twenty-one (11 premature and 10 full-term) neonates with MR imaging evidence of linear radially oriented fan-shaped lesions in the periventricular WM and without dural venous thrombosis were enrolled in this retrospective study. A total of 37 MR imaging examinations were performed at ages ranging from day 0 to 24 months. RESULTS: According to the appearance of linear anomalies on T2-weighted images, we identified 2 main patterns: T2 hypointense lesions without WM cavitations and T2 hypointense lesions associated with linear cysts. The first pattern was found in 17 examinations performed between 0 and 44 days of life; the second pattern was found in another 14 examinations performed between 6 days and 4 months of life. Five examinations performed between 9 and 24 months of life showed a reduction in volume and hyperintense signal intensity of the periventricularWMon T2-weighted and FLAIR images. CONCLUSIONS: Subtle linear WM lesions with the same anatomic distribution of DMVs may be evident in premature and full-term neonates without signs of major venous thrombosis, both in the acute and subacute phases. Their appearance and evolution suggest that transient DMV engorgement/ thrombosis may be responsible for WM damage that can lead to a PVL-like pattern.

AB - BACKGROUND AND PURPOSE: Different and specific MR imaging patterns of lesions involving WM are widely defined in neonatal encephalopathy. The aim of this study was to describe a novel MR imaging pattern of damage characterized by the abnormal prominence of DMVs in premature and full-term neonates. MATERIALS AND METHODS: Twenty-one (11 premature and 10 full-term) neonates with MR imaging evidence of linear radially oriented fan-shaped lesions in the periventricular WM and without dural venous thrombosis were enrolled in this retrospective study. A total of 37 MR imaging examinations were performed at ages ranging from day 0 to 24 months. RESULTS: According to the appearance of linear anomalies on T2-weighted images, we identified 2 main patterns: T2 hypointense lesions without WM cavitations and T2 hypointense lesions associated with linear cysts. The first pattern was found in 17 examinations performed between 0 and 44 days of life; the second pattern was found in another 14 examinations performed between 6 days and 4 months of life. Five examinations performed between 9 and 24 months of life showed a reduction in volume and hyperintense signal intensity of the periventricularWMon T2-weighted and FLAIR images. CONCLUSIONS: Subtle linear WM lesions with the same anatomic distribution of DMVs may be evident in premature and full-term neonates without signs of major venous thrombosis, both in the acute and subacute phases. Their appearance and evolution suggest that transient DMV engorgement/ thrombosis may be responsible for WM damage that can lead to a PVL-like pattern.

UR - http://www.scopus.com/inward/record.url?scp=84455188634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84455188634&partnerID=8YFLogxK

U2 - 10.3174/ajnr.A2687

DO - 10.3174/ajnr.A2687

M3 - Article

C2 - 21960491

AN - SCOPUS:84455188634

VL - 32

SP - 2030

EP - 2036

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 11

ER -