Default mode network activity in bipolar disorder

Niccolò Zovetti, Maria Gloria Rossetti, Cinzia Perlini, Eleonora Maggioni, Pietro Bontempi, Marcella Bellani, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review


Since its discovery in 1997, the default mode network (DMN) and its components have been extensively studied in both healthy individuals and psychiatric patients. Several studies have investigated possible DMN alterations in specific mental conditions such as bipolar disorder (BD). In this review, we describe current evidence from resting-state functional magnetic resonance imaging studies with the aim to understand possible changes in the functioning of the DMN in BD. Overall, several types of analyses including seed-based and independent component have been conducted on heterogeneous groups of patients highlighting different results. Despite the differences, findings seem to indicate that BD is associated with alterations in both frontal and posterior DMN structures, mainly in the prefrontal, posterior cingulate and inferior parietal cortices. We conclude this review by suggesting possible future research directions.

Original languageEnglish
Article numbere166
JournalEpidemiology and Psychiatric Sciences
Publication statusPublished - Sep 8 2020


  • Bipolar disorder
  • default mode network
  • resting-state fMRI
  • review

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health


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