DEFB1 gene 5' untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

T. J. Wilson, M. Jobim, L. Segat, A. M. Bianco, P. H. Salim, P. Portela, L. F. Jobim, D. C. Damin, G. Schwartsmann, R. Roesler, S. Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

The possible association of three DEFB1 gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn's disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5'-UTR DEFB1 SNPs and susceptibility/protection to IBDs cannot be drawn, our results suggest a possible involvement of DEFB1 gene in inflammatory bowel diseases, especially with the colonic localization of Crohn's disease.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalInternational Journal of Immunogenetics
Volume41
Issue number2
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)
  • Medicine(all)

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