DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population

Ronaldo Celerino da Silva, Heidi Lacerda Alves da Cruz, Lucas André Cavalcanti Brandão, Rafael Lima Guimarães, Lilian Maria Lapa Montenegro, Haiana Charifker Schindler, Ludovica Segat, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play animportant role in lung mucosal immunity. In our association study we analyzed three DEFB1functional polymorphisms −52G>A (rs1799946), −44C>G (rs1800972) and −20G>A (rs11362)in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no associ-ation was found between the studied DEFB1 polymorphisms and the disease. However wecannot exclude that this lack of association could be due to the low number of subjectsanalyzed, as suggested by the low statistical power achieved for the three analyzed SNPs(values between 0.16 and 0.50).

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalBrazilian Journal of Microbiology
Volume47
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • DEFB1
  • Genotyping
  • Innate immunity
  • Polymorphisma
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology

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  • Cite this

    da Silva, R. C., da Cruz, H. L. A., Brandão, L. A. C., Guimarães, R. L., Montenegro, L. M. L., Schindler, H. C., Segat, L., & Crovella, S. (2016). DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. Brazilian Journal of Microbiology, 47(2), 389-393. https://doi.org/10.1016/j.bjm.2015.09.001