Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

F. Dallegri; A. Ballestrero; L. Ottonello; F. Patrone

Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

F. Dallegri, A. Ballestrero, L. Ottonello, F. Patrone

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

Original language	English
Pages (from-to)	58-61
Number of pages	4
Journal	Clinical and Experimental Immunology
Volume	77
Issue number	1
Publication status	Published - 1989

ASJC Scopus subject areas

Immunology

Cite this

@article{48d514fbc730480ebe74afce575fa867,

title = "Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients",

abstract = "Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.",

author = "F. Dallegri and A. Ballestrero and L. Ottonello and F. Patrone",

year = "1989",

language = "English",

volume = "77",

pages = "58--61",

journal = "Clinical and Experimental Immunology",

issn = "0009-9104",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

AU - Dallegri, F.

AU - Ballestrero, A.

AU - Ottonello, L.

AU - Patrone, F.

PY - 1989

Y1 - 1989

N2 - Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

AB - Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

UR - http://www.scopus.com/inward/record.url?scp=0024374993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024374993&partnerID=8YFLogxK

M3 - Article

C2 - 2766579

AN - SCOPUS:0024374993

VL - 77

SP - 58

EP - 61

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 1

ER -

Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this