Abstract
Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.
| Original language | English |
|---|---|
| Pages (from-to) | 58-61 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Immunology |
| Volume | 77 |
| Issue number | 1 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
Cite this
Dallegri, F., Ballestrero, A., Ottonello, L., & Patrone, F. (1989). Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients. Clinical and Experimental Immunology, 77(1), 58-61.