Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

F. Dallegri; A. Ballestrero; L. Ottonello; F. Patrone

Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

F. Dallegri, A. Ballestrero, L. Ottonello, F. Patrone

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

Original language	English
Pages (from-to)	58-61
Number of pages	4
Journal	Clinical and Experimental Immunology
Volume	77
Issue number	1
Publication status	Published - 1989

ASJC Scopus subject areas

Immunology

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title = "Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients",

abstract = "Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.",

author = "F. Dallegri and A. Ballestrero and L. Ottonello and F. Patrone",

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AU - Patrone, F.

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AB - Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

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