Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients

F. Dallegri, A. Ballestrero, L. Ottonello, F. Patrone

Research output: Contribution to journalArticle

Abstract

Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalClinical and Experimental Immunology
Volume77
Issue number1
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Immunology

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