Abstract
Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.
| Original language | English |
|---|---|
| Pages (from-to) | 58-61 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Immunology |
| Volume | 77 |
| Issue number | 1 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
Cite this
Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients. / Dallegri, F.; Ballestrero, A.; Ottonello, L.; Patrone, F.
In: Clinical and Experimental Immunology, Vol. 77, No. 1, 1989, p. 58-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients
AU - Dallegri, F.
AU - Ballestrero, A.
AU - Ottonello, L.
AU - Patrone, F.
PY - 1989
Y1 - 1989
N2 - Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.
AB - Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024374993&partnerID=8YFLogxK
M3 - Article
VL - 77
SP - 58
EP - 61
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
SN - 0009-9104
IS - 1
ER -