Defective expression of the dihydrofolate reductase gene in patients with 5q- syndrome

Rosangela Invernizzi, Sergio Comincini, Erica Travaglino, Angelica Facoetti, Isabella Romajoli, Rosanna Nano

Research output: Contribution to journalArticle

Abstract

We evaluated dihydrofolate-reductase (DHFR) gene expression in the marrow cells of 6 cases of 5q- syndrome and 8 patients with other myelodysplastic syndromes. DHFR mRNA was decreased in 5q- cases. Losses of transcripts were associated with low erythroblast DHFR activity, decreased progenitor growth in vitro and reduced erythroblast proliferative rate.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalHaematologica
Volume88
Issue number4
Publication statusPublished - Apr 1 2003

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Keywords

  • 5q- syndrome
  • Dihydrofolate reductase
  • Gene expression
  • Real-time PCR

ASJC Scopus subject areas

  • Hematology

Cite this

Invernizzi, R., Comincini, S., Travaglino, E., Facoetti, A., Romajoli, I., & Nano, R. (2003). Defective expression of the dihydrofolate reductase gene in patients with 5q- syndrome. Haematologica, 88(4), 471-474.