Defective expression of the dihydrofolate reductase gene in patients with 5q- syndrome

Rosangela Invernizzi, Sergio Comincini, Erica Travaglino, Angelica Facoetti, Isabella Romajoli, Rosanna Nano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We evaluated dihydrofolate-reductase (DHFR) gene expression in the marrow cells of 6 cases of 5q- syndrome and 8 patients with other myelodysplastic syndromes. DHFR mRNA was decreased in 5q- cases. Losses of transcripts were associated with low erythroblast DHFR activity, decreased progenitor growth in vitro and reduced erythroblast proliferative rate.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalHaematologica
Volume88
Issue number4
Publication statusPublished - Apr 1 2003

Fingerprint

Tetrahydrofolate Dehydrogenase
Erythroblasts
Genes
Myelodysplastic Syndromes
Bone Marrow
Gene Expression
Messenger RNA
Growth
Chromosome 5q Deletion Syndrome

Keywords

  • 5q- syndrome
  • Dihydrofolate reductase
  • Gene expression
  • Real-time PCR

ASJC Scopus subject areas

  • Hematology

Cite this

Defective expression of the dihydrofolate reductase gene in patients with 5q- syndrome. / Invernizzi, Rosangela; Comincini, Sergio; Travaglino, Erica; Facoetti, Angelica; Romajoli, Isabella; Nano, Rosanna.

In: Haematologica, Vol. 88, No. 4, 01.04.2003, p. 471-474.

Research output: Contribution to journalArticle

Invernizzi, R, Comincini, S, Travaglino, E, Facoetti, A, Romajoli, I & Nano, R 2003, 'Defective expression of the dihydrofolate reductase gene in patients with 5q- syndrome', Haematologica, vol. 88, no. 4, pp. 471-474.
Invernizzi, Rosangela ; Comincini, Sergio ; Travaglino, Erica ; Facoetti, Angelica ; Romajoli, Isabella ; Nano, Rosanna. / Defective expression of the dihydrofolate reductase gene in patients with 5q- syndrome. In: Haematologica. 2003 ; Vol. 88, No. 4. pp. 471-474.
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