Defective Fas ligand production in lymphocytes from MS patients

Beatrice Macchi, Claudia Matteucci, Ugo Nocentini, Santina Tacconi, Veronica Pagnini, Antonio Mastino, Carlo Caltagirone

Research output: Contribution to journalArticlepeer-review

Abstract

In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo.

Original languageEnglish
Pages (from-to)4113-4116
Number of pages4
JournalNeuroReport
Volume12
Issue number18
Publication statusPublished - Dec 21 2001

Keywords

  • Apoptosis
  • EDSS
  • Fas ligand
  • Lymphocytes
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neuroscience(all)

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