Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis

Ferdinando Di Cunto, Sara Imarisio, Emilio Hirsch, Vania Broccoli, Alessandro Bulfone, Antonio Migheli, Cristiana Atzori, Emilia Turco, Roberta Triolo, Gian Paolo Dotto, Lorenzo Silengo, Fiorella Altruda

Research output: Contribution to journalArticlepeer-review

Abstract

Citron-kinase (Citron-K) has been proposed by in vitro studies as a crucial effector of Rho in regulation of cytokinesis. To further investigate in vivo its biologic functions, we have inactivated Citron-K gene in mice by homologous recombination. Citron-K(-/-) mice grow at slower rates, are severely ataxic, and die before adulthood as a consequence of fatal seizures. Their brains display defective neurogenesis, with depletion of specific neuronal populations. These abnormalities arise during development of the central nervous system due to altered cytokinesis and massive apoptosis. Our results indicate that Citron-K is essential for cytokinesis in vivo but only in specific neuronal precursors. Moreover, they suggest a novel molecular mechanism for a subset of human malformative syndromes of the CNS.

Original languageEnglish
Pages (from-to)115-127
Number of pages13
JournalNeuron
Volume28
Issue number1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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