Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: Deficiency of an aspirin-independent mechanism?

Piera Vie Ro, Sergio Cortelazzo, Tiziano Bar Bu I, Giovanni De Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

Platelets from 6 out of 10 patients with myeloproliferative disorders showed only a single reversible wave of aggregation when challenged with platelet activating factor (PAF). Preexposure to subthreshold concentrations of adrenaline resulted in a full irreversible response to PAF. Aspirin, however, removed this synergism. In the remaining 4 patients, PAF induced a full response but aspirin abolished the synergism with adrenaline in 2 of them. In platelets from all controls aspirin failed to abolish the synergism between PAF and adrenaline. It is suggested that patients with myeloproliferative disorders lack – to varying degrees – an aspirin-independent mechanism which amplifies the primary response to PAF. Such a mechanism could involve the products of arachidonic acid metabolism catalyzed by lipoxygenase.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalPathophysiology of Haemostasis and Thrombosis
Volume16
Issue number1
DOIs
Publication statusPublished - 1986

Keywords

  • Aspirin
  • Cyclo-oxygenase
  • Lipoxygenase
  • Myeloproliferative disorders
  • Platelet activating factor
  • Platelet aggregation

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

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