Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: Deficiency of an aspirin-independent mechanism?

Piera Vie Ro; Sergio Cortelazzo; Tiziano Bar Bu I; Giovanni De Gaetano

doi:10.1159/000215266

Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: Deficiency of an aspirin-independent mechanism?

Piera Vie Ro, Sergio Cortelazzo, Tiziano Bar Bu I, Giovanni De Gaetano

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Research output: Contribution to journal › Article › peer-review

Abstract

Platelets from 6 out of 10 patients with myeloproliferative disorders showed only a single reversible wave of aggregation when challenged with platelet activating factor (PAF). Preexposure to subthreshold concentrations of adrenaline resulted in a full irreversible response to PAF. Aspirin, however, removed this synergism. In the remaining 4 patients, PAF induced a full response but aspirin abolished the synergism with adrenaline in 2 of them. In platelets from all controls aspirin failed to abolish the synergism between PAF and adrenaline. It is suggested that patients with myeloproliferative disorders lack – to varying degrees – an aspirin-independent mechanism which amplifies the primary response to PAF. Such a mechanism could involve the products of arachidonic acid metabolism catalyzed by lipoxygenase.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Pathophysiology of Haemostasis and Thrombosis
Volume	16
Issue number	1
DOIs	https://doi.org/10.1159/000215266
Publication status	Published - 1986

Keywords

Aspirin
Cyclo-oxygenase
Lipoxygenase
Myeloproliferative disorders
Platelet activating factor
Platelet aggregation

ASJC Scopus subject areas

Hematology
Physiology (medical)

Access to Document

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Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders : Deficiency of an aspirin-independent mechanism? / Vie Ro, Piera; Cortelazzo, Sergio; Bar Bu I, Tiziano; De Gaetano, Giovanni.

In: Pathophysiology of Haemostasis and Thrombosis, Vol. 16, No. 1, 1986, p. 27-33.

Research output: Contribution to journal › Article › peer-review

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abstract = "Platelets from 6 out of 10 patients with myeloproliferative disorders showed only a single reversible wave of aggregation when challenged with platelet activating factor (PAF). Preexposure to subthreshold concentrations of adrenaline resulted in a full irreversible response to PAF. Aspirin, however, removed this synergism. In the remaining 4 patients, PAF induced a full response but aspirin abolished the synergism with adrenaline in 2 of them. In platelets from all controls aspirin failed to abolish the synergism between PAF and adrenaline. It is suggested that patients with myeloproliferative disorders lack – to varying degrees – an aspirin-independent mechanism which amplifies the primary response to PAF. Such a mechanism could involve the products of arachidonic acid metabolism catalyzed by lipoxygenase.",

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