Abstract
Platelets from 6 out of 10 patients with myeloproliferative disorders showed only a single reversible wave of aggregation when challenged with platelet activating factor (PAF). Preexposure to subthreshold concentrations of adrenaline resulted in a full irreversible response to PAF. Aspirin, however, removed this synergism. In the remaining 4 patients, PAF induced a full response but aspirin abolished the synergism with adrenaline in 2 of them. In platelets from all controls aspirin failed to abolish the synergism between PAF and adrenaline. It is suggested that patients with myeloproliferative disorders lack – to varying degrees – an aspirin-independent mechanism which amplifies the primary response to PAF. Such a mechanism could involve the products of arachidonic acid metabolism catalyzed by lipoxygenase.
Original language | English |
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Pages (from-to) | 27-33 |
Number of pages | 7 |
Journal | Pathophysiology of Haemostasis and Thrombosis |
Volume | 16 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1986 |
Keywords
- Aspirin
- Cyclo-oxygenase
- Lipoxygenase
- Myeloproliferative disorders
- Platelet activating factor
- Platelet aggregation
ASJC Scopus subject areas
- Hematology
- Physiology (medical)