Peripheral blood mononuclear cells from patients with essential mixed cryoglobulinemia were investigated for the ability to induce suppressor cell activity (SCA) following in vitro exposure to concanavalin A (Con A). The generation of Con A-SCA is significantly impaired in essential mixed cryoglobulinemia compared to the healthy controls. No correlation was found between Con A-SCA and the clinical or laboratory parameters of the disease. This impaired ability to induce Con A-SCA in essential mixed cryoglobulinemia reflects a functional T-cell defect, which may play a role in the pathogenesis of the disease.
|Number of pages||6|
|Journal||Journal of Clinical and Laboratory Immunology|
|Publication status||Published - 1982|
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