Defective suppressor cell activity in essential mixed cryoglobulinemia

P. L. Meroni, W. Barcellini, C. Messina, G. De Bartolo, F. Capsoni, F. Invernizzi

Research output: Contribution to journalArticle

Abstract

Peripheral blood mononuclear cells from patients with essential mixed cryoglobulinemia were investigated for the ability to induce suppressor cell activity (SCA) following in vitro exposure to concanavalin A (Con A). The generation of Con A-SCA is significantly impaired in essential mixed cryoglobulinemia compared to the healthy controls. No correlation was found between Con A-SCA and the clinical or laboratory parameters of the disease. This impaired ability to induce Con A-SCA in essential mixed cryoglobulinemia reflects a functional T-cell defect, which may play a role in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalJournal of Clinical and Laboratory Immunology
Volume8
Issue number3
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Immunology

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