Defective suppressor cell activity in essential mixed cryoglobulinemia

P. L. Meroni, W. Barcellini, C. Messina, G. De Bartolo, F. Capsoni, F. Invernizzi

Research output: Contribution to journalArticlepeer-review


Peripheral blood mononuclear cells from patients with essential mixed cryoglobulinemia were investigated for the ability to induce suppressor cell activity (SCA) following in vitro exposure to concanavalin A (Con A). The generation of Con A-SCA is significantly impaired in essential mixed cryoglobulinemia compared to the healthy controls. No correlation was found between Con A-SCA and the clinical or laboratory parameters of the disease. This impaired ability to induce Con A-SCA in essential mixed cryoglobulinemia reflects a functional T-cell defect, which may play a role in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalJournal of Clinical and Laboratory Immunology
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology


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