Defibrillation threshold in pigs: Biphasic versus monophasic shocks

A. S. Montenero, G. Bombardieri, C. Barilaro, A. Natale, F. Biscione, P. Santarelli, G. F. Possati

Research output: Contribution to journalArticle

Abstract

The AICD is an effective means of treating patients suffering for potentially fatal ventricular arrhythmias. A clinical advantage would be gained if the energy requirements for defibrillation could be reduced. The purpose of this study was to demonstrate better efficacy of biphasic shock than monophasic in lowering defibrillation threshold. We determined the minimum energy requirements for defibrillation using biphasic and monophasic pulses maintaining constant shock duration and patch surface area. The mean of triplicate DFTs was obtained in 8 anesthetized open chest healthy pigs. Each pig was randomized to receive biphasic followed by monophasic shocks or viceversa. Results showed that the DFTs were significantly lower using biphasic shock than monophasic (4.9 ± 3.9 J vs 11.4 ± 10.0 J, p <0.03). In our model, using controlled experimental conditions, both peak voltage and delivered energy lower using biphasic shocks. Our results confirm that the biphasic shock is more effective than monophasic in defibrillating the heart.

Original languageEnglish
Pages (from-to)851-854
Number of pages4
JournalNew Trends in Arrhythmias
Volume7
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Defibrillation threshold in pigs: Biphasic versus monophasic shocks'. Together they form a unique fingerprint.

  • Cite this

    Montenero, A. S., Bombardieri, G., Barilaro, C., Natale, A., Biscione, F., Santarelli, P., & Possati, G. F. (1991). Defibrillation threshold in pigs: Biphasic versus monophasic shocks. New Trends in Arrhythmias, 7(4), 851-854.