Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome

C. Franceschi, F. Licastro, M. Chiricolo, F. Bonetti, M. Zannotti, N. Fabris, E. Mocchegiani, M. P. Fantini, P. Paolucci, M. Masi

Research output: Contribution to journalArticlepeer-review

Abstract

The immune competence of the T lymphocyte system was studied in 28 noninstitutionalized subjects with Down's syndrome (DS) and were compared with sex- and age-matched healthy controls. The ability of enriched T lymphocytes to respond to 3 different T cell stimulants revealed a selective impairment of T lymphocyte subset(s). Subjects with DS showed normal responsiveness in allogeneic mixed lymphocyte reactions, but their response to phytohemagglutinin and in autologous mixed lymphocyte reactions was severely impaired. Non-T cells from DS subjects stimulated equally well both normal and DS allogeneic T lymphocytes. The blood concentration of serum thymic factor in the majority of DS subjects was much lower than that found in age-matched healthy controls. These data support the hypothesis that a deficiency of the T-dependent regulatory system is an intrinsic feature of DS and confirm the precocious aging of the immune system in these subjects.

Original languageEnglish
Pages (from-to)2161-2164
Number of pages4
JournalJournal of Immunology
Volume126
Issue number6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Immunology

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