Abstract
The immune competence of the T lymphocyte system was studied in 28 noninstitutionalized subjects with Down's syndrome (DS) and were compared with sex- and age-matched healthy controls. The ability of enriched T lymphocytes to respond to 3 different T cell stimulants revealed a selective impairment of T lymphocyte subset(s). Subjects with DS showed normal responsiveness in allogeneic mixed lymphocyte reactions, but their response to phytohemagglutinin and in autologous mixed lymphocyte reactions was severely impaired. Non-T cells from DS subjects stimulated equally well both normal and DS allogeneic T lymphocytes. The blood concentration of serum thymic factor in the majority of DS subjects was much lower than that found in age-matched healthy controls. These data support the hypothesis that a deficiency of the T-dependent regulatory system is an intrinsic feature of DS and confirm the precocious aging of the immune system in these subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 2161-2164 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 126 |
| Issue number | 6 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Immunology
Cite this
Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome. / Franceschi, C.; Licastro, F.; Chiricolo, M.; Bonetti, F.; Zannotti, M.; Fabris, N.; Mocchegiani, E.; Fantini, M. P.; Paolucci, P.; Masi, M.
In: Journal of Immunology, Vol. 126, No. 6, 1981, p. 2161-2164.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome
AU - Franceschi, C.
AU - Licastro, F.
AU - Chiricolo, M.
AU - Bonetti, F.
AU - Zannotti, M.
AU - Fabris, N.
AU - Mocchegiani, E.
AU - Fantini, M. P.
AU - Paolucci, P.
AU - Masi, M.
PY - 1981
Y1 - 1981
N2 - The immune competence of the T lymphocyte system was studied in 28 noninstitutionalized subjects with Down's syndrome (DS) and were compared with sex- and age-matched healthy controls. The ability of enriched T lymphocytes to respond to 3 different T cell stimulants revealed a selective impairment of T lymphocyte subset(s). Subjects with DS showed normal responsiveness in allogeneic mixed lymphocyte reactions, but their response to phytohemagglutinin and in autologous mixed lymphocyte reactions was severely impaired. Non-T cells from DS subjects stimulated equally well both normal and DS allogeneic T lymphocytes. The blood concentration of serum thymic factor in the majority of DS subjects was much lower than that found in age-matched healthy controls. These data support the hypothesis that a deficiency of the T-dependent regulatory system is an intrinsic feature of DS and confirm the precocious aging of the immune system in these subjects.
AB - The immune competence of the T lymphocyte system was studied in 28 noninstitutionalized subjects with Down's syndrome (DS) and were compared with sex- and age-matched healthy controls. The ability of enriched T lymphocytes to respond to 3 different T cell stimulants revealed a selective impairment of T lymphocyte subset(s). Subjects with DS showed normal responsiveness in allogeneic mixed lymphocyte reactions, but their response to phytohemagglutinin and in autologous mixed lymphocyte reactions was severely impaired. Non-T cells from DS subjects stimulated equally well both normal and DS allogeneic T lymphocytes. The blood concentration of serum thymic factor in the majority of DS subjects was much lower than that found in age-matched healthy controls. These data support the hypothesis that a deficiency of the T-dependent regulatory system is an intrinsic feature of DS and confirm the precocious aging of the immune system in these subjects.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019450109&partnerID=8YFLogxK
M3 - Article
C2 - 6453157
AN - SCOPUS:0019450109
VL - 126
SP - 2161
EP - 2164
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 6
ER -