Deficiency of lymphocyte lectin-dependent cytotoxicity in myelodysplastic syndromes

L. Fontana, G. de Sanctis, G. de Rossi, V. Bottari, M. C. Petti, F. Ensoli, D. Pasqualetti, F. Mandelli

Research output: Contribution to journalArticlepeer-review

Abstract

We studied a group of patients with myelodysplastic syndromes (MDS) for surface markers and cytotoxic activities of peripheral blood mononuclear cells (PBMNC). The results indicate a significant increase in the total count of CD11b+, Leu7+ and CD16+ with a percent reduction in CD4+. A reduction in PHA-induced cellular cytotoxicity (PHA-ICC) and NK activity were found. A similar phenotype was found both in refractory anemia (RA) and (RA) with excess of blasts (RAEB/RAEB-t). However, the functional activities reached the normal level only in RA patients; while in RAEB/RAEB-t patients a significant reduction was detected in PHA-ICC and NK activity.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalActa Haematologica
Volume82
Issue number1
DOIs
Publication statusPublished - 1989

Keywords

  • Antibody-dependent cellular cytotoxicity
  • Myelodysplastic syndromes
  • Natural killer activity
  • PHA-induced cellular cytotoxicity
  • Single cell cytotoxicity assay
  • Surface markers

ASJC Scopus subject areas

  • Hematology

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