Deficiency of lymphocyte lectin-dependent cytotoxicity in myelodysplastic syndromes

L. Fontana; G. de Sanctis; G. de Rossi; V. Bottari; M. C. Petti; F. Ensoli; D. Pasqualetti; F. Mandelli

doi:10.1159/000205269

Deficiency of lymphocyte lectin-dependent cytotoxicity in myelodysplastic syndromes

L. Fontana, G. de Sanctis, G. de Rossi, V. Bottari, M. C. Petti, F. Ensoli, D. Pasqualetti, F. Mandelli

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

We studied a group of patients with myelodysplastic syndromes (MDS) for surface markers and cytotoxic activities of peripheral blood mononuclear cells (PBMNC). The results indicate a significant increase in the total count of CD11b+, Leu7+ and CD16+ with a percent reduction in CD4+. A reduction in PHA-induced cellular cytotoxicity (PHA-ICC) and NK activity were found. A similar phenotype was found both in refractory anemia (RA) and (RA) with excess of blasts (RAEB/RAEB-t). However, the functional activities reached the normal level only in RA patients; while in RAEB/RAEB-t patients a significant reduction was detected in PHA-ICC and NK activity.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Acta Haematologica
Volume	82
Issue number	1
DOIs	https://doi.org/10.1159/000205269
Publication status	Published - 1989

Keywords

Antibody-dependent cellular cytotoxicity
Myelodysplastic syndromes
Natural killer activity
PHA-induced cellular cytotoxicity
Single cell cytotoxicity assay
Surface markers

ASJC Scopus subject areas

Hematology

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10.1159/000205269

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title = "Deficiency of lymphocyte lectin-dependent cytotoxicity in myelodysplastic syndromes",

abstract = "We studied a group of patients with myelodysplastic syndromes (MDS) for surface markers and cytotoxic activities of peripheral blood mononuclear cells (PBMNC). The results indicate a significant increase in the total count of CD11b+, Leu7+ and CD16+ with a percent reduction in CD4+. A reduction in PHA-induced cellular cytotoxicity (PHA-ICC) and NK activity were found. A similar phenotype was found both in refractory anemia (RA) and (RA) with excess of blasts (RAEB/RAEB-t). However, the functional activities reached the normal level only in RA patients; while in RAEB/RAEB-t patients a significant reduction was detected in PHA-ICC and NK activity.",

keywords = "Antibody-dependent cellular cytotoxicity, Myelodysplastic syndromes, Natural killer activity, PHA-induced cellular cytotoxicity, Single cell cytotoxicity assay, Surface markers",

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AU - Fontana, L.

AU - de Sanctis, G.

AU - de Rossi, G.

AU - Bottari, V.

AU - Petti, M. C.

AU - Ensoli, F.

AU - Pasqualetti, D.

AU - Mandelli, F.

PY - 1989

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N2 - We studied a group of patients with myelodysplastic syndromes (MDS) for surface markers and cytotoxic activities of peripheral blood mononuclear cells (PBMNC). The results indicate a significant increase in the total count of CD11b+, Leu7+ and CD16+ with a percent reduction in CD4+. A reduction in PHA-induced cellular cytotoxicity (PHA-ICC) and NK activity were found. A similar phenotype was found both in refractory anemia (RA) and (RA) with excess of blasts (RAEB/RAEB-t). However, the functional activities reached the normal level only in RA patients; while in RAEB/RAEB-t patients a significant reduction was detected in PHA-ICC and NK activity.

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