Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache

Raffaele Lodi, Stefano Iotti, Pietro Cortelli, Giulia Pierangeli, Sabina Cevoli, Valeria Clementi, Stefano Soriani, Pasquale Montagna, Bruno Barbiroli

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We used phosphorus magnetic resonance spectroscopy to assess in vivo the brain cytosolic free magnesium concentration and the free energy released by the reaction of adenosine triphosphate (ATP) hydrolysis (ΔGATPhyd), the latter being an index of the cell's bioenergetics condition. We studied 78 patients with migraine in attack-free periods (7 with migraine stroke, 13 with migraine with prolonged aura, 37 with migraine with typical aura or basilar migraine, and 21 with migraine without aura), and 13 patients with cluster headache. In the occipital lobes of all subgroups of migraine and in cluster headache patients cytosolic free [Mg2+] as well as the free energy released by the reaction of ATP hydrolysis were significantly reduced. Among migraine patients, the level of free energy released by the reaction of ATP hydrolysis and the cytosolic free [Mg2+] showed a trend in keeping with the severity of clinical phenotype, both showing the lowest values in patients with migraine stroke and the highest in patients with migraine without aura. These results support our current hypothesis that the reduction in free [Mg2+] in tissues with mitochondrial dysfunction is secondary to the bioenergetics deficit, and are against a primary role of low brain cytosolic free [Mg2+] in causing the bioenergetics deficit in headache.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalBrain Research Bulletin
Volume54
Issue number4
DOIs
Publication statusPublished - Mar 1 2001

Fingerprint

Cluster Headache
Migraine Disorders
Magnesium
Energy Metabolism
Migraine with Aura
Brain
Migraine without Aura
Hydrolysis
Adenosine Triphosphate
Stroke
Occipital Lobe
Phosphorus
Headache
Magnetic Resonance Spectroscopy
Phenotype

Keywords

  • Brain bioenergetics
  • Cluster headache
  • Magnesium
  • Migraine
  • Phosphorus MR spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache. / Lodi, Raffaele; Iotti, Stefano; Cortelli, Pietro; Pierangeli, Giulia; Cevoli, Sabina; Clementi, Valeria; Soriani, Stefano; Montagna, Pasquale; Barbiroli, Bruno.

In: Brain Research Bulletin, Vol. 54, No. 4, 01.03.2001, p. 437-441.

Research output: Contribution to journalArticle

Lodi, Raffaele ; Iotti, Stefano ; Cortelli, Pietro ; Pierangeli, Giulia ; Cevoli, Sabina ; Clementi, Valeria ; Soriani, Stefano ; Montagna, Pasquale ; Barbiroli, Bruno. / Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache. In: Brain Research Bulletin. 2001 ; Vol. 54, No. 4. pp. 437-441.
@article{24dbd8fd22084be988e239931f21cc9f,
title = "Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache",
abstract = "We used phosphorus magnetic resonance spectroscopy to assess in vivo the brain cytosolic free magnesium concentration and the free energy released by the reaction of adenosine triphosphate (ATP) hydrolysis (ΔGATPhyd), the latter being an index of the cell's bioenergetics condition. We studied 78 patients with migraine in attack-free periods (7 with migraine stroke, 13 with migraine with prolonged aura, 37 with migraine with typical aura or basilar migraine, and 21 with migraine without aura), and 13 patients with cluster headache. In the occipital lobes of all subgroups of migraine and in cluster headache patients cytosolic free [Mg2+] as well as the free energy released by the reaction of ATP hydrolysis were significantly reduced. Among migraine patients, the level of free energy released by the reaction of ATP hydrolysis and the cytosolic free [Mg2+] showed a trend in keeping with the severity of clinical phenotype, both showing the lowest values in patients with migraine stroke and the highest in patients with migraine without aura. These results support our current hypothesis that the reduction in free [Mg2+] in tissues with mitochondrial dysfunction is secondary to the bioenergetics deficit, and are against a primary role of low brain cytosolic free [Mg2+] in causing the bioenergetics deficit in headache.",
keywords = "Brain bioenergetics, Cluster headache, Magnesium, Migraine, Phosphorus MR spectroscopy",
author = "Raffaele Lodi and Stefano Iotti and Pietro Cortelli and Giulia Pierangeli and Sabina Cevoli and Valeria Clementi and Stefano Soriani and Pasquale Montagna and Bruno Barbiroli",
year = "2001",
month = "3",
day = "1",
doi = "10.1016/S0361-9230(01)00440-3",
language = "English",
volume = "54",
pages = "437--441",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache

AU - Lodi, Raffaele

AU - Iotti, Stefano

AU - Cortelli, Pietro

AU - Pierangeli, Giulia

AU - Cevoli, Sabina

AU - Clementi, Valeria

AU - Soriani, Stefano

AU - Montagna, Pasquale

AU - Barbiroli, Bruno

PY - 2001/3/1

Y1 - 2001/3/1

N2 - We used phosphorus magnetic resonance spectroscopy to assess in vivo the brain cytosolic free magnesium concentration and the free energy released by the reaction of adenosine triphosphate (ATP) hydrolysis (ΔGATPhyd), the latter being an index of the cell's bioenergetics condition. We studied 78 patients with migraine in attack-free periods (7 with migraine stroke, 13 with migraine with prolonged aura, 37 with migraine with typical aura or basilar migraine, and 21 with migraine without aura), and 13 patients with cluster headache. In the occipital lobes of all subgroups of migraine and in cluster headache patients cytosolic free [Mg2+] as well as the free energy released by the reaction of ATP hydrolysis were significantly reduced. Among migraine patients, the level of free energy released by the reaction of ATP hydrolysis and the cytosolic free [Mg2+] showed a trend in keeping with the severity of clinical phenotype, both showing the lowest values in patients with migraine stroke and the highest in patients with migraine without aura. These results support our current hypothesis that the reduction in free [Mg2+] in tissues with mitochondrial dysfunction is secondary to the bioenergetics deficit, and are against a primary role of low brain cytosolic free [Mg2+] in causing the bioenergetics deficit in headache.

AB - We used phosphorus magnetic resonance spectroscopy to assess in vivo the brain cytosolic free magnesium concentration and the free energy released by the reaction of adenosine triphosphate (ATP) hydrolysis (ΔGATPhyd), the latter being an index of the cell's bioenergetics condition. We studied 78 patients with migraine in attack-free periods (7 with migraine stroke, 13 with migraine with prolonged aura, 37 with migraine with typical aura or basilar migraine, and 21 with migraine without aura), and 13 patients with cluster headache. In the occipital lobes of all subgroups of migraine and in cluster headache patients cytosolic free [Mg2+] as well as the free energy released by the reaction of ATP hydrolysis were significantly reduced. Among migraine patients, the level of free energy released by the reaction of ATP hydrolysis and the cytosolic free [Mg2+] showed a trend in keeping with the severity of clinical phenotype, both showing the lowest values in patients with migraine stroke and the highest in patients with migraine without aura. These results support our current hypothesis that the reduction in free [Mg2+] in tissues with mitochondrial dysfunction is secondary to the bioenergetics deficit, and are against a primary role of low brain cytosolic free [Mg2+] in causing the bioenergetics deficit in headache.

KW - Brain bioenergetics

KW - Cluster headache

KW - Magnesium

KW - Migraine

KW - Phosphorus MR spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=0035279577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035279577&partnerID=8YFLogxK

U2 - 10.1016/S0361-9230(01)00440-3

DO - 10.1016/S0361-9230(01)00440-3

M3 - Article

C2 - 11306197

AN - SCOPUS:0035279577

VL - 54

SP - 437

EP - 441

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 4

ER -