Abstract
Allogeneic bone marrow transplant recipients maintain normal peripheral blood counts long term, suggesting durable support from engrafted stem cells. In order to investigate late hemopoietic reconstitution at the level of committed and early progenitors (LTC-IC), we studied 64 long-term survivors at a median interval of 6 years (range: 2-20) after allogeneic bone marrow transplant. CFU-GM and BFU-E numbers did not differ from normal controls; CFU-GEMM were found to be significantly decreased (1.2 ± 0.2/105 vs 3.1 ± 0.4, P = 0.001). The most remarkable defect was however, the low frequency of LTC-IC (3.2 ± 0.6/106 vs 54.2 ± 9.3, P = 0.0001) that did not improve with time and did not correlate with phase of the disease, conditioning regimen, CMV infections or GVHD. Number of infused cells and CFU-GM content of marrow grafts did not seem to influence the number of LTC-IC. This study documents a significantly reduced number of early progenitors in BMT patients despite normal numbers of committed progenitors and normal peripheral blood counts. This finding may suggest a permanent reduction of the stem cell reservoir after allogeneic bone marrow transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 1011-1017 |
| Number of pages | 7 |
| Journal | Bone Marrow Transplantation |
| Volume | 19 |
| Issue number | 10 |
| Publication status | Published - May 2 1997 |
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Keywords
- Allogeneic bone marrow transplant
- Long-term survivors
- LTC-IC
ASJC Scopus subject areas
- Hematology
- Transplantation
Cite this
Deficient reconstitution of early progenitors after allogeneic bone marrow transplantation. / Podestà, M.; Piaggio, G.; Frassoni, F.; Pitto, A.; Mordini, N.; Bregante, S.; Valeriani, A.; Bacigalupo, A.
In: Bone Marrow Transplantation, Vol. 19, No. 10, 02.05.1997, p. 1011-1017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deficient reconstitution of early progenitors after allogeneic bone marrow transplantation
AU - Podestà, M.
AU - Piaggio, G.
AU - Frassoni, F.
AU - Pitto, A.
AU - Mordini, N.
AU - Bregante, S.
AU - Valeriani, A.
AU - Bacigalupo, A.
PY - 1997/5/2
Y1 - 1997/5/2
N2 - Allogeneic bone marrow transplant recipients maintain normal peripheral blood counts long term, suggesting durable support from engrafted stem cells. In order to investigate late hemopoietic reconstitution at the level of committed and early progenitors (LTC-IC), we studied 64 long-term survivors at a median interval of 6 years (range: 2-20) after allogeneic bone marrow transplant. CFU-GM and BFU-E numbers did not differ from normal controls; CFU-GEMM were found to be significantly decreased (1.2 ± 0.2/105 vs 3.1 ± 0.4, P = 0.001). The most remarkable defect was however, the low frequency of LTC-IC (3.2 ± 0.6/106 vs 54.2 ± 9.3, P = 0.0001) that did not improve with time and did not correlate with phase of the disease, conditioning regimen, CMV infections or GVHD. Number of infused cells and CFU-GM content of marrow grafts did not seem to influence the number of LTC-IC. This study documents a significantly reduced number of early progenitors in BMT patients despite normal numbers of committed progenitors and normal peripheral blood counts. This finding may suggest a permanent reduction of the stem cell reservoir after allogeneic bone marrow transplantation.
AB - Allogeneic bone marrow transplant recipients maintain normal peripheral blood counts long term, suggesting durable support from engrafted stem cells. In order to investigate late hemopoietic reconstitution at the level of committed and early progenitors (LTC-IC), we studied 64 long-term survivors at a median interval of 6 years (range: 2-20) after allogeneic bone marrow transplant. CFU-GM and BFU-E numbers did not differ from normal controls; CFU-GEMM were found to be significantly decreased (1.2 ± 0.2/105 vs 3.1 ± 0.4, P = 0.001). The most remarkable defect was however, the low frequency of LTC-IC (3.2 ± 0.6/106 vs 54.2 ± 9.3, P = 0.0001) that did not improve with time and did not correlate with phase of the disease, conditioning regimen, CMV infections or GVHD. Number of infused cells and CFU-GM content of marrow grafts did not seem to influence the number of LTC-IC. This study documents a significantly reduced number of early progenitors in BMT patients despite normal numbers of committed progenitors and normal peripheral blood counts. This finding may suggest a permanent reduction of the stem cell reservoir after allogeneic bone marrow transplantation.
KW - Allogeneic bone marrow transplant
KW - Long-term survivors
KW - LTC-IC
UR - http://www.scopus.com/inward/record.url?scp=0030972870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030972870&partnerID=8YFLogxK
M3 - Article
C2 - 9169645
AN - SCOPUS:0030972870
VL - 19
SP - 1011
EP - 1017
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 10
ER -