Deficit of verb generation in nondemented patients with Parkinson's disease

Patrice Péran, Olivier Rascol, J. F. Démonet, Pierre Celsis, Jean L. Nespoulous, Bruno Dubois, Dominique Cardebat

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Clinical and neuroimaging studies have shown that verb processing suggests a preferential participation of a prefrontal network, which is dysfunctional in Parkinson's disease (PD). To assess a verb processing deficit in PD, we compared noun- and verb-generation tasks for 34 nondemented PD patients (according to the Dementia Rating Scale) with 34 matched normal subjects, using two intracategory tasks (noun/noun and verb/verb generation) and two intercategory tasks (noun/verb and verb/noun generation). PD patients were significantly impaired in the two tasks involving verb production, i.e., verb/verb and noun/verb generation, whereas their performance was similar to those of controls in the two tasks requiring noun production. For the two impaired tasks, we assessed 1) the influence of lexical competition that corresponds to the presence of several candidate words for a given stimulus; 2) the influence of slight cognitive dysfunction; and 3) the influence of motor deficit. Significant correlations were found between DRS scores and performance on the noun/verb task, and no significant correlations were found between lexical competition or motor deficit and performance. The specific deficit for verb production in PD patients is discussed in relation to deficits affecting either action or grammatical representations.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalMovement Disorders
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

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Parkinson Disease
Neuroimaging
Dementia

Keywords

  • Language
  • Parkinson
  • Verb
  • Word generation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Péran, P., Rascol, O., Démonet, J. F., Celsis, P., Nespoulous, J. L., Dubois, B., & Cardebat, D. (2003). Deficit of verb generation in nondemented patients with Parkinson's disease. Movement Disorders, 18(2), 150-156. https://doi.org/10.1002/mds.10306

Deficit of verb generation in nondemented patients with Parkinson's disease. / Péran, Patrice; Rascol, Olivier; Démonet, J. F.; Celsis, Pierre; Nespoulous, Jean L.; Dubois, Bruno; Cardebat, Dominique.

In: Movement Disorders, Vol. 18, No. 2, 01.02.2003, p. 150-156.

Research output: Contribution to journalArticle

Péran, P, Rascol, O, Démonet, JF, Celsis, P, Nespoulous, JL, Dubois, B & Cardebat, D 2003, 'Deficit of verb generation in nondemented patients with Parkinson's disease', Movement Disorders, vol. 18, no. 2, pp. 150-156. https://doi.org/10.1002/mds.10306
Péran P, Rascol O, Démonet JF, Celsis P, Nespoulous JL, Dubois B et al. Deficit of verb generation in nondemented patients with Parkinson's disease. Movement Disorders. 2003 Feb 1;18(2):150-156. https://doi.org/10.1002/mds.10306
Péran, Patrice ; Rascol, Olivier ; Démonet, J. F. ; Celsis, Pierre ; Nespoulous, Jean L. ; Dubois, Bruno ; Cardebat, Dominique. / Deficit of verb generation in nondemented patients with Parkinson's disease. In: Movement Disorders. 2003 ; Vol. 18, No. 2. pp. 150-156.
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