Deficits in memory and visuospatial learning correlate with regional hippocampal atrophy in MS

Giulia Longoni, Maria A. Rocca, Elisabetta Pagani, Gianna C. Riccitelli, Bruno Colombo, Mariaemma Rodegher, Andrea Falini, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review


The hippocampus has a critical role in episodic memory and visuospatial learning and consolidation. We assessed the patterns of whole and regional hippocampal atrophy in a large group of multiple sclerosis (MS) patients, and their correlations with neuropsychological impairment. From 103 MS patients and 28 healthy controls (HC), brain dual-echo and high-resolution 3D T1-weighted images were acquired using a 3.0-Tesla scanner. All patients underwent a neuropsychological assessment of hippocampal-related cognitive functions, including Paired Associate Word Learning, Short Story, delayed recall of Rey-Osterrieth Complex Figure and Paced Auditory Serial Attention tests. The hippocampi were manually segmented and volumes derived. Regional atrophy distribution was assessed using a radial mapping analysis. Correlations between hippocampal atrophy and clinical, neuropsychological and MRI metrics were also evaluated. Hippocampal volume was reduced in MS patients vs HC (p 

Original languageEnglish
Pages (from-to)435-444
Number of pages10
JournalBrain Structure and Function
Issue number1
Publication statusPublished - Jan 1 2015


  • Cognitive impairment
  • Hippocampus
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Radial mapping

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Histology
  • Medicine(all)

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