Defining cerebrospinal fluid HIV RNA escape: Editorial review AIDS

Alan Winston, Andrea Antinori, Paola Cinque, Howard S. Fox, Magnus Gisslen, Timothy J. Henrich, Scott Letendre, Deborah Persaud, Richard W. Price, Serena Spudich

Research output: Contribution to journalReview article


Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy. Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal fluid (CSF) which is generally termed CSF HIV RNA escape. Defining CSF HIV RNA escape from a virological point of view, a symptomatology point of view and its management has many challenges with several different definitions being utilized. In this editorial, we outline proposed consensus definitions of CSF HIV RNA escape with consideration of virological, symptomatology and management aspects of this condition.

Original languageEnglish
Pages (from-to)S107-S111
Number of pages5
Issue numberSuppl 2
Publication statusPublished - Dec 1 2019


  • central nervous system
  • cerebrospinal fluid
  • cerebrospinal fluid escape

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Winston, A., Antinori, A., Cinque, P., Fox, H. S., Gisslen, M., Henrich, T. J., Letendre, S., Persaud, D., Price, R. W., & Spudich, S. (2019). Defining cerebrospinal fluid HIV RNA escape: Editorial review AIDS. AIDS, 33(Suppl 2), S107-S111.