Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Raphaèle Seror, Hendrika Bootsma, Alain Saraux, Simon J. Bowman, Elke Theander, Johan G. Brun, Gabriel Baron, Véronique Le Guern, Valérie Devauchelle-Pensec, Manel Ramos-Casals, Valeria Valim, Thomas Dörner, Athanasios Tzioufas, Jacques Eric Gottenberg, Roser Solans Laqué, Thomas Mandl, Eric Hachulla, Kathy L. Sivils, Wan Fai Ng, Anne Laure FauchaisStefano Bombardieri, Roberta Priori, Elena Bartoloni, Vincent Goeb, Sonja Praprotnik, Takayuki Sumida, Sumusu Nishiyama, Roberto Caporali, Aike A. Kruize, Cristina Vollenweider, Philippe Ravaud, Petra Meiners, Pilar Brito-Zerón, Claudio Vitali, Xavier Mariette, Roberto Gerli, Cees Kallenberg, Salvatore De Vita, Frederic Demoulins, Carlomaurizio Montecucco, Matija Tomsic, Hal Scofield, Guido Valesini

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives To define disease activity levels, minimal clinically important improvement (MCII) and patientacceptable symptom state (PASS) with the primary Sjögren's syndrome (SS) disease activity indexes: European League Against Rheumatism (EULAR) SS disease activity index (ESSDAI) and EULAR SS patientreported index (ESSPRI). Methods For 790 patients from two large prospective cohorts, ESSDAI, physician evaluation of disease activity, ESSPRI and patients' satisfaction with their current health status were recorded. Receiver operating characteristic curve analyses and anchoring methods were used to estimate disease activity levels of ESSDAI and the PASS of ESSPRI. At follow-up visit, patients and physicians assessed, respectively, whether symptoms and disease activity have improved or not. An anchoring method based on this evaluation was used to estimate MCII of ESSDAI and ESSPRI. Results Low-activity (ESSDAI

Original languageEnglish
Pages (from-to)382-389
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume75
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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