Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Raphaèle Seror; Hendrika Bootsma; Alain Saraux; Simon J. Bowman; Elke Theander; Johan G. Brun; Gabriel Baron; Véronique Le Guern; Valérie Devauchelle-Pensec; Manel Ramos-Casals; Valeria Valim; Thomas Dörner; Athanasios Tzioufas; Jacques Eric Gottenberg; Roser Solans Laqué; Thomas Mandl; Eric Hachulla; Kathy L. Sivils; Wan Fai Ng; Anne Laure Fauchais; Stefano Bombardieri; Roberta Priori; Elena Bartoloni; Vincent Goeb; Sonja Praprotnik; Takayuki Sumida; Sumusu Nishiyama; Roberto Caporali; Aike A. Kruize; Cristina Vollenweider; Philippe Ravaud; Petra Meiners; Pilar Brito-Zerón; Claudio Vitali; Xavier Mariette; Roberto Gerli; Cees Kallenberg; Salvatore De Vita; Frederic Demoulins; Carlomaurizio Montecucco; Matija Tomsic; Hal Scofield; Guido Valesini

doi:10.1136/annrheumdis-2014-206008

Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)

Raphaèle Seror, Hendrika Bootsma, Alain Saraux, Simon J. Bowman, Elke Theander, Johan G. Brun, Gabriel Baron, Véronique Le Guern, Valérie Devauchelle-Pensec, Manel Ramos-Casals, Valeria Valim, Thomas Dörner, Athanasios Tzioufas, Jacques Eric Gottenberg, Roser Solans Laqué, Thomas Mandl, Eric Hachulla, Kathy L. Sivils, Wan Fai Ng, Anne Laure FauchaisStefano Bombardieri, Roberta Priori, Elena Bartoloni, Vincent Goeb, Sonja Praprotnik, Takayuki Sumida, Sumusu Nishiyama, Roberto Caporali, Aike A. Kruize, Cristina Vollenweider, Philippe Ravaud, Petra Meiners, Pilar Brito-Zerón, Claudio Vitali, Xavier Mariette, Roberto Gerli, Cees Kallenberg, Salvatore De Vita, Frederic Demoulins, Carlomaurizio Montecucco, Matija Tomsic, Hal Scofield, Guido Valesini

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives To define disease activity levels, minimal clinically important improvement (MCII) and patientacceptable symptom state (PASS) with the primary Sjögren's syndrome (SS) disease activity indexes: European League Against Rheumatism (EULAR) SS disease activity index (ESSDAI) and EULAR SS patientreported index (ESSPRI). Methods For 790 patients from two large prospective cohorts, ESSDAI, physician evaluation of disease activity, ESSPRI and patients' satisfaction with their current health status were recorded. Receiver operating characteristic curve analyses and anchoring methods were used to estimate disease activity levels of ESSDAI and the PASS of ESSPRI. At follow-up visit, patients and physicians assessed, respectively, whether symptoms and disease activity have improved or not. An anchoring method based on this evaluation was used to estimate MCII of ESSDAI and ESSPRI. Results Low-activity (ESSDAI

Original language	English
Pages (from-to)	382-389
Number of pages	8
Journal	Annals of the Rheumatic Diseases
Volume	75
Issue number	2
DOIs	https://doi.org/10.1136/annrheumdis-2014-206008
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Rheumatology
Immunology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Allergy

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10.1136/annrheumdis-2014-206008

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Seror, R., Bootsma, H., Saraux, A., Bowman, S. J., Theander, E., Brun, J. G., Baron, G., Le Guern, V., Devauchelle-Pensec, V., Ramos-Casals, M., Valim, V., Dörner, T., Tzioufas, A., Gottenberg, J. E., Laqué, R. S., Mandl, T., Hachulla, E., Sivils, K. L., Ng, W. F., ... Valesini, G. (2016). Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). Annals of the Rheumatic Diseases, 75(2), 382-389. https://doi.org/10.1136/annrheumdis-2014-206008

Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). / Seror, Raphaèle; Bootsma, Hendrika; Saraux, Alain; Bowman, Simon J.; Theander, Elke; Brun, Johan G.; Baron, Gabriel; Le Guern, Véronique; Devauchelle-Pensec, Valérie; Ramos-Casals, Manel; Valim, Valeria; Dörner, Thomas; Tzioufas, Athanasios; Gottenberg, Jacques Eric; Laqué, Roser Solans; Mandl, Thomas; Hachulla, Eric; Sivils, Kathy L.; Ng, Wan Fai; Fauchais, Anne Laure; Bombardieri, Stefano; Priori, Roberta; Bartoloni, Elena; Goeb, Vincent; Praprotnik, Sonja; Sumida, Takayuki; Nishiyama, Sumusu; Caporali, Roberto; Kruize, Aike A.; Vollenweider, Cristina; Ravaud, Philippe; Meiners, Petra; Brito-Zerón, Pilar; Vitali, Claudio; Mariette, Xavier; Gerli, Roberto; Kallenberg, Cees; De Vita, Salvatore; Demoulins, Frederic; Montecucco, Carlomaurizio; Tomsic, Matija; Scofield, Hal; Valesini, Guido.

In: Annals of the Rheumatic Diseases, Vol. 75, No. 2, 01.02.2016, p. 382-389.

Research output: Contribution to journal › Article › peer-review

Seror, R, Bootsma, H, Saraux, A, Bowman, SJ, Theander, E, Brun, JG, Baron, G, Le Guern, V, Devauchelle-Pensec, V, Ramos-Casals, M, Valim, V, Dörner, T, Tzioufas, A, Gottenberg, JE, Laqué, RS, Mandl, T, Hachulla, E, Sivils, KL, Ng, WF, Fauchais, AL, Bombardieri, S, Priori, R, Bartoloni, E, Goeb, V, Praprotnik, S, Sumida, T, Nishiyama, S, Caporali, R, Kruize, AA, Vollenweider, C, Ravaud, P, Meiners, P, Brito-Zerón, P, Vitali, C, Mariette, X, Gerli, R, Kallenberg, C, De Vita, S, Demoulins, F, Montecucco, C, Tomsic, M, Scofield, H & Valesini, G 2016, 'Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)', Annals of the Rheumatic Diseases, vol. 75, no. 2, pp. 382-389. https://doi.org/10.1136/annrheumdis-2014-206008

Seror R, Bootsma H, Saraux A, Bowman SJ, Theander E, Brun JG et al. Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). Annals of the Rheumatic Diseases. 2016 Feb 1;75(2):382-389. https://doi.org/10.1136/annrheumdis-2014-206008

Seror, Raphaèle ; Bootsma, Hendrika ; Saraux, Alain ; Bowman, Simon J. ; Theander, Elke ; Brun, Johan G. ; Baron, Gabriel ; Le Guern, Véronique ; Devauchelle-Pensec, Valérie ; Ramos-Casals, Manel ; Valim, Valeria ; Dörner, Thomas ; Tzioufas, Athanasios ; Gottenberg, Jacques Eric ; Laqué, Roser Solans ; Mandl, Thomas ; Hachulla, Eric ; Sivils, Kathy L. ; Ng, Wan Fai ; Fauchais, Anne Laure ; Bombardieri, Stefano ; Priori, Roberta ; Bartoloni, Elena ; Goeb, Vincent ; Praprotnik, Sonja ; Sumida, Takayuki ; Nishiyama, Sumusu ; Caporali, Roberto ; Kruize, Aike A. ; Vollenweider, Cristina ; Ravaud, Philippe ; Meiners, Petra ; Brito-Zerón, Pilar ; Vitali, Claudio ; Mariette, Xavier ; Gerli, Roberto ; Kallenberg, Cees ; De Vita, Salvatore ; Demoulins, Frederic ; Montecucco, Carlomaurizio ; Tomsic, Matija ; Scofield, Hal ; Valesini, Guido. / Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). In: Annals of the Rheumatic Diseases. 2016 ; Vol. 75, No. 2. pp. 382-389.

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abstract = "Objectives To define disease activity levels, minimal clinically important improvement (MCII) and patientacceptable symptom state (PASS) with the primary Sj{\"o}gren's syndrome (SS) disease activity indexes: European League Against Rheumatism (EULAR) SS disease activity index (ESSDAI) and EULAR SS patientreported index (ESSPRI). Methods For 790 patients from two large prospective cohorts, ESSDAI, physician evaluation of disease activity, ESSPRI and patients' satisfaction with their current health status were recorded. Receiver operating characteristic curve analyses and anchoring methods were used to estimate disease activity levels of ESSDAI and the PASS of ESSPRI. At follow-up visit, patients and physicians assessed, respectively, whether symptoms and disease activity have improved or not. An anchoring method based on this evaluation was used to estimate MCII of ESSDAI and ESSPRI. Results Low-activity (ESSDAI",

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AU - Bootsma, Hendrika

AU - Saraux, Alain

AU - Bowman, Simon J.

AU - Theander, Elke

AU - Brun, Johan G.

AU - Baron, Gabriel

AU - Le Guern, Véronique

AU - Devauchelle-Pensec, Valérie

AU - Ramos-Casals, Manel

AU - Valim, Valeria

AU - Dörner, Thomas

AU - Tzioufas, Athanasios

AU - Gottenberg, Jacques Eric

AU - Laqué, Roser Solans

AU - Mandl, Thomas

AU - Hachulla, Eric

AU - Sivils, Kathy L.

AU - Ng, Wan Fai

AU - Fauchais, Anne Laure

AU - Bombardieri, Stefano

AU - Priori, Roberta

AU - Bartoloni, Elena

AU - Goeb, Vincent

AU - Praprotnik, Sonja

AU - Sumida, Takayuki

AU - Nishiyama, Sumusu

AU - Caporali, Roberto

AU - Kruize, Aike A.

AU - Vollenweider, Cristina

AU - Ravaud, Philippe

AU - Meiners, Petra

AU - Brito-Zerón, Pilar

AU - Vitali, Claudio

AU - Mariette, Xavier

AU - Gerli, Roberto

AU - Kallenberg, Cees

AU - De Vita, Salvatore

AU - Demoulins, Frederic

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