Defining the course of tumefactive multiple sclerosis: a large retrospective multicentre study

Maria Di Gregorio, Valentina Liliana Adriana Torri Clerici, Giuseppe Fenu, Lorenzo Gaetani, Antonio Gallo, Paola Cavalla, Paolo Ragonese, Pietro Annovazzi, Alberto Gajofatto, Luca Prosperini, Doriana Landi, Carolina Gabri Nicoletti, Caterina Di Carmine, Rocco Totaro, Viviana Nociti, Chiara De Fino, Diana Ferraro, Valentina Tomassini, Carla Tortorella, Isabella RighiniMaria Pia Amato, Alessia Manni, Damiano Paolicelli, Pietro Iaffaldano, Roberta Lanzillo, Marcello Moccia, Fabio Buttari, Roberta Fantozzi, Raffaella Cerqua, Sara Zagaglia, Deborah Farina, Giovanna De Luca, Maria Chiara Buscarinu, Federica Pinardi, Eleonora Cocco, Claudio Gasperini, Claudio Solaro, Massimiliano Di Filippo

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INTRODUCTION: Tumefactive multiple sclerosis (TuMS), i.e. a MS onset presenting with tumefactive demyelinating lesions (TDLs), is a diagnostic and therapeutic challenge. We performed a multicentre retrospective study to describe the clinical characteristics and the prognostic factors of TuMS.METHODS: 102 TuMS patients were included in this retrospective study. Demographic, clinical, MRI, laboratory data and treatment choices were collected.RESULTS: TuMS was found to affect women more than men (F:M=2.4), with a young adulthood onset (median age: 29.5 years, range: 11-68, IQR: 38). At onset, 52% of TuMS patients presented with the involvement of > 1 functional system and 24.5% of them with multiple TDLs. TDLs most frequently presented with an infiltrative MRI pattern (38.7%). CSF IgG oligoclonal bands were often demonstrated (76.6%). In 25.3% of the cases, > 1 acute-phase treatment was administered. and almost a half of the patients (46.6%) was treated with high efficacy treatments. After a median follow-up of 2.3 years (range: 0.1-10.7, IQR: 3.4), the median EDSS was 1.5 (range: 0-7, IQR: 2). Independent risk factors for reaching an EDSS ≥ 3 were: a higher age at onset (OR: 1.08, 95% CI: 1.03-1.14, p
Original languageEnglish
JournalEur. J. Neurol.
Publication statusPublished - Apr 10 2021


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