The sensitivity of the renal vasculature to endothelin-1 together with the effect of the peptide on the kidney prompted investigators to study the role of endothelin-1 in renal pathophysiology. The kidney expresses both endothelin(A) and endothelin(B) receptors, which differ from species to species. Experiments employing specific endothelin receptor antagonists in experimental animals have suggested a role for endothelin-1 in ischaemia-induced acute renal failure and renal disease progression.
|Number of pages||5|
|Journal||Current Opinion in Nephrology and Hypertension|
|Publication status||Published - 1995|
ASJC Scopus subject areas
- Internal Medicine