Defining the role of endothelins in renal pathophysiology on the basis of selective and unselective endothelin receptor antagonist studies

Research output: Contribution to journalArticle

Abstract

The sensitivity of the renal vasculature to endothelin-1 together with the effect of the peptide on the kidney prompted investigators to study the role of endothelin-1 in renal pathophysiology. The kidney expresses both endothelin(A) and endothelin(B) receptors, which differ from species to species. Experiments employing specific endothelin receptor antagonists in experimental animals have suggested a role for endothelin-1 in ischaemia-induced acute renal failure and renal disease progression.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalCurrent Opinion in Nephrology and Hypertension
Volume4
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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