Defining the role of the Bcl-2 family proteins in Huntington's disease

J. Sassone, A. Maraschi, F. Sassone, V. Silani, A. Ciammola

Research output: Contribution to journalArticle

Abstract

B-cell lymphoma 2 (Bcl-2) family proteins regulate survival, mitochondria morphology dynamics and metabolism in many cell types including neurons. Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat tract in the IT15 gene that encodes for the protein huntingtin (htt). In vitro and in vivo models of HD and HD patients' tissues show abnormal mitochondrial function and increased cell death rates associated with alterations in Bcl-2 family protein expression and localization. This review aims to draw together the information related to Bcl-2 family protein alterations in HD to decipher their potential role in mutated htt-related cell death and mitochondrial dysfunction.

Original languageEnglish
Article numbere772
JournalCell Death and Disease
Volume4
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Bcl-2 family proteins
  • Huntington's disease models
  • Mutated huntingtin

ASJC Scopus subject areas

  • Cell Biology
  • Immunology
  • Cancer Research
  • Cellular and Molecular Neuroscience

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