Definition of therapy resistant epilepsy

A. Baruzzi

Research output: Chapter in Book/Report/Conference proceedingChapter


The prognosis of treated epilepsies has improved over the last 20 years. Some authors have reported an overall remission rate of 60-80% with wide differences depending on the type of epilepsy. The extent of patients' response to therapy becomes evident in the first two years of treatment. In 30% of cases, remission is unstable. We discuss how to define therapy response in practical terms. In recently diagnosed adult patients, monotherapies prove effective in 80% of cases. Addition of a second drug only appears warranted in 10-15% of uncontrolled patients. In chronic patients defined as drug-resistant it may be useful to reconsider monotherapy at high doses or different drug combinations.

Original languageEnglish
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Number of pages4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology


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