Definitive localization of Becker muscular dystrophy in Xp by linkage to a cluster of DNA polymorphisms (DXS43 and DXS9)

S. Fadda, M. Mochi, L. Roncuzzi, S. Sangiorgi, D. Sbarra, M. Zatz, G. Romeo

Research output: Contribution to journalArticle

Abstract

A study of linkage between Becker muscular dystrophy and four X chromosome-specific DNA polymorphisms in 17 kindreds has indicated that this gene is located in Xp, as already anticipated by single pedigree analysis. In particular the DXS43 and DXS9 loci, identified by probes D2 and RC8, respectively, are closely linked to each other and are both located at approximately 15 c M from the Becker locus. These linkage data, together with the previously established linkage between Becker and the DXS7 locus identified by probe L 1.28, indicate that the Becker gene is located in the same region where Duchenne has been mapped and also yield information about relative genetic distances among different DNA polymorphisms of the X chromosome.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalHuman Genetics
Volume71
Issue number1
DOIs
Publication statusPublished - Sep 1985

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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