Degradation studies of antibiotic MDL 62,879 (GE2270A) and revision of the structure

Paolo Tavecchia, Patrizia Gentili, Michael Kurz, Cristina Sottani, Riccardo Bonfichi, Enrico Selva, Sergio Lociuro, Ermenegildo Restelli, Romeo Ciabatti

Research output: Contribution to journalArticlepeer-review

Abstract

Fragments of the thiopeptide antibiotic MDL 62,879 (GE2270A) were prepared under mild degradation conditions. Their structures were determined by spectroscopic techniques and by comparison to synthetic reference thiazolyl dipeptides. The two thiazolyl amino acids have stereocenters with S configurations and their sequence is reversed with respect to the structure previously proposed for MDL 62,879.

Original languageEnglish
JournalTetrahedron
Volume51
Issue number16
DOIs
Publication statusPublished - Apr 17 1995

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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