Degradation studies of antibiotic MDL 62,879 (GE2270A) and revision of the structure

Paolo Tavecchia; Patrizia Gentili; Michael Kurz; Cristina Sottani; Riccardo Bonfichi; Enrico Selva; Sergio Lociuro; Ermenegildo Restelli; Romeo Ciabatti

doi:10.1016/0040-4020(95)00171-4

Degradation studies of antibiotic MDL 62,879 (GE2270A) and revision of the structure

Paolo Tavecchia, Patrizia Gentili, Michael Kurz, Cristina Sottani, Riccardo Bonfichi, Enrico Selva, Sergio Lociuro, Ermenegildo Restelli, Romeo Ciabatti

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Fragments of the thiopeptide antibiotic MDL 62,879 (GE2270A) were prepared under mild degradation conditions. Their structures were determined by spectroscopic techniques and by comparison to synthetic reference thiazolyl dipeptides. The two thiazolyl amino acids have stereocenters with S configurations and their sequence is reversed with respect to the structure previously proposed for MDL 62,879.

Original language	English
Journal	Tetrahedron
Volume	51
Issue number	16
DOIs	https://doi.org/10.1016/0040-4020(95)00171-4
Publication status	Published - Apr 17 1995

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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author = "Paolo Tavecchia and Patrizia Gentili and Michael Kurz and Cristina Sottani and Riccardo Bonfichi and Enrico Selva and Sergio Lociuro and Ermenegildo Restelli and Romeo Ciabatti",

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AU - Tavecchia, Paolo

AU - Gentili, Patrizia

AU - Kurz, Michael

AU - Sottani, Cristina

AU - Bonfichi, Riccardo

AU - Selva, Enrico

AU - Lociuro, Sergio

AU - Restelli, Ermenegildo

AU - Ciabatti, Romeo

PY - 1995/4/17

Y1 - 1995/4/17

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AB - Fragments of the thiopeptide antibiotic MDL 62,879 (GE2270A) were prepared under mild degradation conditions. Their structures were determined by spectroscopic techniques and by comparison to synthetic reference thiazolyl dipeptides. The two thiazolyl amino acids have stereocenters with S configurations and their sequence is reversed with respect to the structure previously proposed for MDL 62,879.

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