Dehydroepiandrosterone sulfate and bone resorption rates as reflected by serum levels of C-terminal telopeptide of type I collagen: A study in healthy men

V. Carnevale, A. Scillitani, E. Vecci, E. D'Erasmo, E. Romagnoli, F. Paglia, J. Pepe, V. Baldini, C. Santori, S. De Geronimo, S. Minisola

Research output: Contribution to journalArticle

Abstract

Sex steroid hormones contribute to the physiological regulation of bone turnover in males. To address this issue, we investigated serum estradiol (E2), total testosterone (T), and DHEAS concentrations, along with serum levels of carboxy-terminal telopeptide of type I collagen (sCTx), in a sample of 76 healthy men aged 23 to 87. The concentration of sCTx declined with age. Both T and DHEAS, at variance with E2, showed a significant age-related decline. T, DHEAS and sCTx significantly (p2) was a significant independent predictor of sCTx (p=0.0001). Our results show that adrenal androgens play a crucial role in regulating bone resorption in aging men.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalJournal of Endocrinological Investigation
Volume28
Issue number2
Publication statusPublished - 2005

Keywords

  • Bone resorption
  • DHEAS
  • Estradiol
  • Serum carboxy-terminal telopeptide of type I collagen
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology

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    Carnevale, V., Scillitani, A., Vecci, E., D'Erasmo, E., Romagnoli, E., Paglia, F., Pepe, J., Baldini, V., Santori, C., De Geronimo, S., & Minisola, S. (2005). Dehydroepiandrosterone sulfate and bone resorption rates as reflected by serum levels of C-terminal telopeptide of type I collagen: A study in healthy men. Journal of Endocrinological Investigation, 28(2), 102-105.